| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
IGF1 Receptor (IGF1R) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, FACS, IF, IHC, WB |
| Recommended dilutions: |
Flow Cytometry: 1:10-1:50, IHC (Paraffin): 1:50-1:100, Immunofluorescence: 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the IGF1R antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This IGF1R antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P08069 |
| Purity: |
Purified |
| Description: |
Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity, It is crucial for tumor transformation and survival of malignant cell, Ligand binding activates the receptor kinase, Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway, Shc and 14-3-3 proteins, The activated IGF1 receptor is involved in cell growth and survival control, The result of activating the MAPK pathway is increased cellular proliferation, and tyrosines phosphorylation of multiple substrates, leading to receptor autophosphorylation, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis, IGF1R is a tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1) |
| Immunogen: |
A portion of amino acids 51-77 from the human protein was used as the immunogen for this IGF1R antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the IGF1R antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
IGF1 Receptor (IGF1R) |
| Short name: |
IGF1 Receptor Antibody (IGF1R) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
insulin-like growth factor 1 (somatomedin C) Receptor (Antibody to) (insulin-like growth factor 1 receptor) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CD221 and IGFIR and IGFR and JTK13, Cell surfaces, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046326 and positive regulation of glucose import and biological process this GO :0046579 and positive regulation of Ras protein signal transduction and biological process this GO :0048009 and insulin-like growth factor receptor signaling pathway and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process this GO :0048146 and positive regulation of fibroblast proliferation and biological process this GO :0048286 and lung alveolus development and biological process this GO :0048468 and cell development and biological process this GO :0048661 and positive regulation of smooth muscle cell proliferation and biological process this GO :0048754 and branching morphogenesis of an epithelial tube and biological process this GO :0048839 and inner ear development and biological process this GO :0050650 and chondroitin sulfate proteoglycan biosynthetic process and biological process this GO :0050679 and positive regulation of epithelial cell proliferation and biological process this GO :0050731 and positive regulation of peptidyl-tyrosine phosphorylation and biological process this GO :0051246 and regulation of protein metabolic process and biological process this GO :0051450 and myoblast proliferation and biological process this GO :0051897 and positive regulation of protein kinase B signaling and biological process this GO :0060426 and lung vasculature development and biological process this GO :0060463 and lung lobe morphogenesis and biological process this GO :0060509 and Type I pneumocyte differentiation and biological process this GO :0060510 and Type II pneumocyte differentiation and biological process this GO :0060527 and prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis and biological process this GO :0060736 and prostate gland growth and biological process this GO :0060740 and prostate gland epithelium morphogenesis and biological process this GO :0060741 and prostate gland stromal morphogenesis and biological process this GO :0060766 and negative regulation of androgen receptor signaling pathway and biological process this GO :0070373 and negative regulation of ERK1 and ERK2 cascade and biological process this GO :0070886 and positive regulation of calcineurin-NFAT signaling cascade and biological process this GO :0090201 and negative regulation of release of cytochrome c from mitochondria and biological process this GO :0097192 and extrinsic apoptotic signaling pathway in absence of ligand and biological process this GO :2000288 and positive regulation of myoblast proliferation and biological process this GO :2001237 and negative regulation of extrinsic apoptotic signaling pathway and biological process, Extracellular, IGF-I and IGF1A and IGFI, IGF1 and IDBG-53609 and ENSG00000017427 and 3479, IGF1 and IDBG-637164 and ENSBTAG00000011082 and 281239, IGF1R and IDBG-31432 and ENSG00000140443 and 3480, IGF1R and IDBG-628659 and ENSBTAG00000021527 and 281848, Igf1 and IDBG-182955 and ENSMUSG00000020053 and 16000, Igf1r and IDBG-192339 and ENSMUSG00000005533 and 16001, growth factor activity, insulin-like growth factor 1 (somatomedin C), this GO :0001501 and skeletal system development and biological process this GO :0001775 and cell activation and biological process this GO :0001932 and regulation of protein phosphorylation and biological process this GO :0001974 and blood vessel remodeling and biological process this GO :0002576 and platelet degranulation and biological process this GO :0005158 and insulin receptor binding and molecular function this GO :0005159 and insulin-like growth factor receptor binding and molecular function this GO :0005178 and integrin binding and molecular function this GO :0005179 and hormone activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005615 and extracellular space and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006260 and DNA replication and biological process this GO :0006928 and cellular component movement and biological process this GO :0007165 and signal transduction and biological process this GO :0007265 and Ras protein signal transduction and biological process this GO :0007399 and nervous system development and biological process this GO :0007517 and muscle organ development and biological process this GO :0007596 and blood coagulation and biological process this GO :0008083 and growth factor activity and molecular function this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0009441 and glycolate metabolic process and biological process this GO :0010001 and glial cell differentiation and biological process this GO :0010613 and positive regulation of cardiac muscle hypertrophy and biological process this GO :0014068 and positive regulation of phosphatidylinositol 3-kinase signaling and biological process this GO :0014834 and skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration and biological process this GO :0014896 and muscle hypertrophy and biological process this GO :0014904 and myotube cell development and biological process this GO :0014911 and positive regulation of smooth muscle cell migration and biological process this GO :0016942 and insulin-like growth factor binding protein complex and cellular component this GO :0021940 and positive regulation of cerebellar granule cell precursor proliferation and biological process this GO :0030104 and water homeostasis and biological process this GO :0030166 and proteoglycan biosynthetic process and biological process this GO :0030168 and platelet activation and biological process this GO :0030324 and lung development and biological process this GO :0030879 and mammary gland development and biological process this GO :0031017 and exocrine pancreas development and biological process this GO :0031093 and platelet alpha granule lumen and cellular component this GO :0032878 and regulation of establishment or maintenance of cell polarity and biological process this GO :0033160 and positive regulation of protein import into nucleus, this GO :0001965 and G-protein alpha-subunit binding and molecular function this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004714 and transmembrane receptor protein tyrosine kinase activity and molecular function this GO :0005010 and insulin-like growth factor-activated receptor activity and molecular function this GO :0005158 and insulin receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005520 and insulin-like growth factor binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0005901 and caveola and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006955 and immune response and biological process this GO :0007165 and signal transduction and biological process this GO :0007169 and transmembrane receptor protein tyrosine kinase signaling pathway and biological process this GO :0007409 and axonogenesis and biological process this GO :0007420 and brain development and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008286 and insulin receptor signaling pathway and biological process this GO :0008544 and epidermis development and biological process this GO :0009887 and organ morphogenesis and biological process this GO :0010656 and negative regulation of muscle cell apoptotic process and biological process this GO :0014065 and phosphatidylinositol 3-kinase signaling and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016772 and transferase activity, this GO :0001965 : G-protein alpha-subunit binding, this GO :0001965 : G-protein alpha-subunit binding and also this GO :0004672 : protein kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0004714 : transmembrane receptor protein tyrosine kinase activity and also this GO :0005010 : insulin-like growth factor-activated receptor activity and also this GO :0005158 : insulin receptor binding and also this GO :0005515 : protein binding and also this GO :0005520 : insulin-like growth factor binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004672 : protein kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004714 : transmembrane receptor protein tyrosine kinase activity, this GO :0005010 : insulin-like growth factor-activated receptor activity, this GO :0005158 : insulin receptor binding, this GO :0005158 : insulin receptor binding, this GO :0005158 : insulin receptor binding and also this GO :0005159 : insulin-like growth factor receptor binding and also this GO :0005178 : integrin binding and also this GO :0005179 : hormone activity and also this GO :0005515 : protein binding and also this GO :0008083 : growth factor activity, this GO :0005159 : insulin-like growth factor receptor binding, this GO :0005178 : integrin binding, this GO :0005179 : hormone activity, this GO :0005515 : protein binding, this GO :0005515 : protein binding, this GO :0005520 : insulin-like growth factor binding, this GO :0005524 : ATP binding, this GO :0008083 : growth factor activity, this GO :0016772 : transferase activity, this GO :0031994 : insulin-like growth factor I binding, this GO :0042802 : identical protein binding, this GO :0043548 : phosphatidylinositol 3-kinase binding, this GO :0043559 : insulin binding, this GO :0043560 : insulin receptor substrate binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0031994 : insulin-like growth factor I binding and also this GO :0042802 : identical protein binding and also this GO :0043548 : phosphatidylinositol 3-kinase binding and also this GO :0043559 : insulin binding and also this GO :0043560 : insulin receptor substrate binding, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0030010 and establishment of cell polarity and biological process this GO :0030238 and male sex determination and biological process this GO :0030335 and positive regulation of cell migration and biological process this GO :0030879 and mammary gland development and biological process this GO :0031017 and exocrine pancreas development and biological process this GO :0031175 and neuron projection development and biological process this GO :0031994 and insulin-like growth factor I binding and molecular function this GO :0032467 and positive regulation of cytokinesis and biological process this GO :0033197 and response to vitamin E and biological process this GO :0038083 and peptidyl-tyrosine autophosphorylation and biological process this GO :0042802 and identical protein binding and molecular function this GO :0043005 and neuron projection and cellular component this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043231 and intracellular membrane-bounded organelle and cellular component this GO :0043235 and receptor complex and cellular component this GO :0043409 and negative regulation of MAPK cascade and biological process this GO :0043410 and positive regulation of MAPK cascade and biological process this GO :0043433 and negative regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0043548 and phosphatidylinositol 3-kinase binding and molecular function this GO :0043559 and insulin binding and molecular function this GO :0043560 and insulin receptor substrate binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045740 and positive regulation of DNA replication and biological process this GO :0045840 and positive regulation of mitosis and biological process this GO :0046328 and regulation of JNK cascade and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0048009 and insulin-like growth factor receptor signaling pathway and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process this GO :0051054 and positive regulation of DNA metabolic process and biological process this GO :0051262 and protein tetramerization and biological process this GO :0051291 and protein heterooli this GO merization and biological process this GO :0051389 and inactivation of MAPKK activity and biological process this GO :0051897 and positive regulation of protein kinase B signaling and biological process this GO :0051898 and negative regulation of protein kinase B signaling and biological process this GO :0060740 and prostate gland epithelium morphogenesis and biological process this GO :0090031 and positive regulation of steroid hormone biosynthetic process and biological process, translocation and biological process this GO :0034392 and negative regulation of smooth muscle cell apoptotic process and biological process this GO :0035264 and multicellular organism growth and biological process this GO :0035630 and bone mineralization involved in bone maturation and biological process this GO :0040014 and regulation of multicellular organism growth and biological process this GO :0042104 and positive regulation of activated T cell proliferation and biological process this GO :0042523 and positive regulation of tyrosine phosphorylation of Stat5 protein and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043388 and positive regulation of DNA binding and biological process this GO :0043410 and positive regulation of MAPK cascade and biological process this GO :0043568 and positive regulation of insulin-like growth factor receptor signaling pathway and biological process this GO :0044267 and cellular protein metabolic process and biological process this GO :0045087 and innate immune response and biological process this GO :0045445 and myoblast differentiation and biological process this GO :0045669 and positive regulation of osteoblast differentiation and biological process this GO :0045725 and positive regulation of glycogen biosynthetic process and biological process this GO :0045740 and positive regulation of DNA replication and biological process this GO :0045821 and positive regulation of glycolytic process and biological process this GO :0045840 and positive regulation of mitosis and biological process this GO :0045893 and positive regulation of transcription, insulin-like growth factor 1 receptor |
| Identity: |
5465 |
| Gene: |
IGF1R |
More about : IGF1R |
| Long gene name: |
insulin like growth factor 1 receptor |
| Synonyms gene name: |
insulin-like growth factor 1 receptor |
| Synonyms: |
JTK13 CD221 IGFIR MGC18216 IGFR |
| Locus: |
15q26, 3 |
| Discovery year: |
1988-07-07 |
| GenBank acession: |
M69229 |
| Entrez gene record: |
3480 |
| Pubmed identfication: |
1316909 |
| RefSeq identity: |
NM_000875 |
| Classification: |
CD molecules Fibronectin type III domain containing Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000149851 |
| Locus Specific Databases: |
LOVD - Leiden Open Variation Database LRG_1055 |