| Category: |
Antibody |
| Concentration: |
09% sodium azide, 4 with 0, In 1X PBS pH 7 |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
JNK (MAPK8) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IHC, WB, IF |
| Recommended dilutions: |
IHC (Paraffin): 1:10-1:50, Immunofluorescence: 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the JNK antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This JNK antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P45983 |
| Purity: |
Purified |
| Description: |
MAP kinases act as an integration point for multiple biochemical signals, Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis, This kinase is activated by various cell stimuli, This kinase is also involved in UV radiation induced apoptosis, and are involved in a wide variety of cellular processes such as proliferation, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli, apoptosis and differentiation, differentiation, transcription regulation and development, which is thought to be related to cytochrom c-mediated cell death pathway, JNK1 is a member of the MAP kinase family |
| Immunogen: |
A portion of amino acids 358-389 from the human protein was used as the immunogen for this JNK antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the JNK antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
JNK (MAPK8) |
| Short name: |
JNK Antibody (MAPK8) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
JNK (Antibody to) (mitogen-activated protein kinase 8) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
JNK and JNK-46 and JNK1 and JNK1A2 and JNK21B1/2 and PRKM8 and SAPK1 and SAPK1c, MAPK8 and IDBG-631635 and ENSBTAG00000007876 and 539941, MAPK8 and IDBG-73479 and ENSG00000107643 and 5599, Mapk8 and IDBG-148417 and ENSMUSG00000021936 and 26419, alcohol group as acceptor, alcohol group as acceptor and also this GO :0035033 : histone deacetylase regulator activity and also this GO :0042826 : histone deacetylase binding, alcohol group as acceptor and molecular function this GO :0018105 and peptidyl-serine phosphorylation and biological process this GO :0018107 and peptidyl-threonine phosphorylation and biological process this GO :0031063 and regulation of histone deacetylation and biological process this GO :0032091 and negative regulation of protein binding and biological process this GO :0032880 and regulation of protein localization and biological process this GO :0034134 and toll-like receptor 2 signaling pathway and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0034146 and toll-like receptor 5 signaling pathway and biological process this GO :0034162 and toll-like receptor 9 signaling pathway and biological process this GO :0034166 and toll-like receptor 10 signaling pathway and biological process this GO :0035033 and histone deacetylase regulator activity and molecular function this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0038123 and toll-like receptor TLR1:TLR2 signaling pathway and biological process this GO :0038124 and toll-like receptor TLR6:TLR2 signaling pathway and biological process this GO :0042826 and histone deacetylase binding and molecular function this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0045087 and innate immune response and biological process this GO :0046686 and response to cadmium ion and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0051090 and regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0051403 and stress-activated MAPK cascade and biological process this GO :0070301 and cellular response to hydrogen peroxide and biological process this GO :0071222 and cellular response to lipopolysaccharide and biological process this GO :0071260 and cellular response to mechanical stimulus and biological process this GO :0071732 and cellular response to nitric oxide and biological process this GO :0090045 and positive regulation of deacetylase activity and biological process this GO :0097190 and apoptotic signaling pathway and biological process this GO :0097193 and intrinsic apoptotic signaling pathway and biological process this GO :0097300 and programmed necrotic cell death and biological process this GO :1900740 and positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway and biological process this GO :2000017 and positive regulation of determination of dorsal identity and biological process this GO :2001235 and positive regulation of apoptotic signaling pathway and biological process, nuclei, this GO :0000165 and MAPK cascade and biological process this GO :0001503 and ossification and biological process this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002755 and MyD88-dependent toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0003824 and catalytic activity and molecular function this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004705 and JUN kinase activity and molecular function this GO :0004707 and MAP kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005829 and cytosol and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006915 and apoptotic process and biological process this GO :0006950 and response to stress and biological process this GO :0007254 and JNK cascade and biological process this GO :0007258 and JUN phosphorylation and biological process this GO :0009103 and lipopolysaccharide biosynthetic process and biological process this GO :0009411 and response to UV and biological process this GO :0010468 and regulation of gene expression and biological process this GO :0010628 and positive regulation of gene expression and biological process this GO :0016020 and membrane and cellular component this GO :0016301 and kinase activity and molecular function this GO :0016772 and transferase activity, this GO :0003824 : catalytic activity, this GO :0003824 : catalytic activity and also this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004705 : JUN kinase activity and also this GO :0004707 : MAP kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016301 : kinase activity and also this GO :0016772 : transferase activity, this GO :0004672 : protein kinase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004705 : JUN kinase activity, this GO :0004707 : MAP kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016301 : kinase activity, this GO :0016772 : transferase activity, this GO :0016773 : phosphotransferase activity, this GO :0035033 : histone deacetylase regulator activity, this GO :0042826 : histone deacetylase binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0016773 : phosphotransferase activity, transferring phosphorus-containing groups and molecular function this GO :0016773 and phosphotransferase activity, mitogen-activated protein kinase 8 |
| Identity: |
6881 |
| Gene: |
MAPK8 |
More about : MAPK8 |
| Long gene name: |
mitogen-activated protein kinase 8 |
| Synonyms gene: |
PRKM8 |
| Synonyms: |
JNK JNK1 SAPK1 |
| Synonyms name: |
JUN N-terminal kinase |
| Locus: |
10q11, 22 |
| Discovery year: |
1998-04-28 |
| GenBank acession: |
L26318 |
| Entrez gene record: |
5599 |
| Pubmed identfication: |
8137421 8654373 |
| Classification: |
Mitogen-activated protein kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000018172 |