| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
VDAC1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, FACS, IHC, WB |
| Recommended dilutions: |
Flow Cytometry: 1:10-1:50, IHC (Paraffin): 1:50-1:100, Western blot: 1:1000 |
| Notes: |
Titration of the VDAC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This VDAC1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P21796 |
| Purity: |
Purified |
| Description: |
It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV, The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules, The open state has a weak anion selectivity whereas the closed state is cation-selective, The protein may participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis, in the plasma membrane it is involved in cell volume regulation and apoptosis, VDAC1 forms a channel through the mitochondrial outer membrane and also the plasma membrane |
| Immunogen: |
A portion of amino acids 95-124 from the human protein was used as the immunogen for this VDAC1 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the VDAC1 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
VDAC1 |
| Short name: |
VDAC1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
voltage-dependent anion channel 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
PORIN and VDAC-1, VDAC1 and IDBG-240337 and ENSG00000213585 and 7416, VDAC1 and IDBG-645740 and ENSBTAG00000013113 and 282119, Vdac1 and IDBG-171107 and ENSMUSG00000020402 and 22333, nuclei, porin activity, this GO :0001662 and behavioral fear response and biological process this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005741 and mitochondrial outer membrane and cellular component this GO :0005743 and mitochondrial inner membrane and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006820 and anion transport and biological process this GO :0006915 and apoptotic process and biological process this GO :0007268 and synaptic transmission and biological process this GO :0007270 and neuron-neuron synaptic transmission and biological process this GO :0007612 and learning and biological process this GO :0008308 and voltage-gated anion channel activity and molecular function this GO :0015288 and porin activity and molecular function this GO :0016020 and membrane and cellular component this GO :0016032 and viral process and biological process this GO :0030855 and epithelial cell differentiation and biological process this GO :0042645 and mitochondrial nucleoid and cellular component this GO :0044070 and regulation of anion transport and biological process this GO :0046930 and pore complex and cellular component this GO :0055085 and transmembrane transport and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0008308 : voltage-gated anion channel activity and also this GO :0015288 : porin activity, this GO :0008308 : voltage-gated anion channel activity, this GO :0015288 : porin activity, voltage-dependent anion channel 1 |
| Identity: |
12669 |
| Gene: |
VDAC1 |
More about : VDAC1 |
| Long gene name: |
voltage dependent anion channel 1 |
| Synonyms: |
MGC111064 PORIN |
| Locus: |
5q31, 1 |
| Discovery year: |
1993-11-02 |
| Entrez gene record: |
7416 |
| Pubmed identfication: |
7517385 |
| Classification: |
Voltage dependent anion channels |
| Havana BLAST/BLAT: |
OTTHUMG00000129118 |