| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
VDAC1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ICC, IHC-F, IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, 5-1ug/ml, 5-1ug/ml, IHC (Frozen): 0, IHC (Paraffin): 0, Immunocytochemistry: 0, Western blot: 0 |
| Notes: |
Titration of the VDAC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This VDAC1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P21796 |
| Purity: |
Antigen affinity |
| Description: |
At higher transmembrane voltage, At low transmembrane voltage, Huizing et al, The protein is though to form the major pathway for movement of adenine nucleotides through the outer membrane and to be the mitochondrial binding site for hexokinase and glycerol kinase, These features make it likely the protein plays a role in mitochondrial energy metabolism, VDAC1 functions as a selective channel for cations and uncharged molecules, VDAC1 is open for anions such as phosphate, VDAC1 mRNA has a ubiquitous distribution, abundant outer membrane pore-forming protein found in the outer membranes of all eukaryotic mitochondria, and adenine nucleotides, and skeletal muscle, chloride, liver, studied by Northern and Western blot analyses the human tissue distribution of mitochondrial transmembrane metabolite carriers, whereas the VDAC2 isoform appears to be expressed only in the heart, with most pronounced expression in heart, The voltage-dependent anion channel of the outer mitochondrial membrane is a small |
| Immunogen: |
mouse and rat), An amino acid sequence from the middle region of human Voltage-dependent anion channel 1 (RVTQSNFAVGYKTDEF) was used as the immunogen for this VDAC1 antibody (100% homologous in human |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the VDAC1 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
VDAC1 |
| Short name: |
VDAC1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
voltage-dependent anion channel 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
PORIN and VDAC-1, VDAC1 and IDBG-240337 and ENSG00000213585 and 7416, VDAC1 and IDBG-645740 and ENSBTAG00000013113 and 282119, Vdac1 and IDBG-171107 and ENSMUSG00000020402 and 22333, nuclei, porin activity, this GO :0001662 and behavioral fear response and biological process this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005741 and mitochondrial outer membrane and cellular component this GO :0005743 and mitochondrial inner membrane and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006820 and anion transport and biological process this GO :0006915 and apoptotic process and biological process this GO :0007268 and synaptic transmission and biological process this GO :0007270 and neuron-neuron synaptic transmission and biological process this GO :0007612 and learning and biological process this GO :0008308 and voltage-gated anion channel activity and molecular function this GO :0015288 and porin activity and molecular function this GO :0016020 and membrane and cellular component this GO :0016032 and viral process and biological process this GO :0030855 and epithelial cell differentiation and biological process this GO :0042645 and mitochondrial nucleoid and cellular component this GO :0044070 and regulation of anion transport and biological process this GO :0046930 and pore complex and cellular component this GO :0055085 and transmembrane transport and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0008308 : voltage-gated anion channel activity and also this GO :0015288 : porin activity, this GO :0008308 : voltage-gated anion channel activity, this GO :0015288 : porin activity, voltage-dependent anion channel 1 |
| Identity: |
12669 |
| Gene: |
VDAC1 |
More about : VDAC1 |
| Long gene name: |
voltage dependent anion channel 1 |
| Synonyms: |
MGC111064 PORIN |
| Locus: |
5q31, 1 |
| Discovery year: |
1993-11-02 |
| Entrez gene record: |
7416 |
| Pubmed identfication: |
7517385 |
| Classification: |
Voltage dependent anion channels |
| Havana BLAST/BLAT: |
OTTHUMG00000129118 |