| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
NURR1 (NR4A2) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IF, WB, IHC |
| Recommended dilutions: |
IHC (Paraffin): 1:50-1:100, Immunofluorescence: 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the NURR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This NURR1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P43354 |
| Purity: |
Purified |
| Description: |
DJ-1, Genes associated with either PD or Parkinson-related disorders include parkin, In developing DA cells, It belongs to the conserved family of nuclear receptors but lacks an identified ligand and is therefore referred to as an orphan receptor, Nurr1 is a transcription factor that is expressed in the embryonic ventral midbrain and is critical for the development of dopamine (DA) neurons, Nurr1 is also important for the maintenance of adult DA neurons, Nurr1 is required for the expression of several genes important for DA synthesis and function, RXR ligands can promote the survival of DA neurons via a process that depends on Nurr1-RXR heterodimers, The known genetic factors include multiple genes that have been identified in related parkinsonian syndromes, and alpha-synuclein, as well as alpha-synuclein, nuclear receptor-related factor 1 (NURR1), ubiquitin C-terminal hydrolase isozyme L1 (UCH-L1), Parkinson's disease (PD) is a multifactorial disease that appears to arise from the effects of both genetic and environmental influences |
| Immunogen: |
A portion of amino acids 13-42 from the human protein was used as the immunogen for this NURR1 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the NURR1 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
NURR1 (NR4A2) |
| Short name: |
NURR1 Antibody (NR4A2) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
NURR1 (Antibody to) (NR4A2) |
| Alternative technique: |
antibodies |
| Identity: |
7981 |
| Gene: |
NR4A2 |
More about : NR4A2 |
| Long gene name: |
nuclear receptor subfamily 4 group A member 2 |
| Synonyms gene: |
NURR1 |
| Synonyms gene name: |
group A, member 2 , nuclear receptor subfamily 4 |
| Synonyms: |
TINUR NOT RNR1 HZF-3 |
| Locus: |
2q22-q23 |
| Discovery year: |
1997-07-11 |
| GenBank acession: |
X75918 |
| Pubmed identfication: |
7706727 |
| Classification: |
Nuclear hormone receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000131950 |