| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Claudin 2 (CLDN2) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IHC, WB |
| Recommended dilutions: |
IHC (Paraffin): 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the Claudin 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This Claudin 2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P57739 |
| Purity: |
Antigen affinity |
| Description: |
CLDN2 has been shown to form paracellular channels for water, Furthermore, Mice that are deficient in the protein have reduced reabsorption of Na+ in the proximal tubule, Similar results have been obtained with cultured cells, [Wiki], as overexpression in CLDN2 lacking cells leads to increase of permeability for small cations, consistent with a role in paracellular transport, Claudin-2 is expressed in cation-leaky epithelia such as that of the kidney proximal tubule |
| Immunogen: |
A portion of amino acids 135-164 from the human protein was used as the immunogen for this Claudin 2 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the Claudin 2 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Claudin 2 (CLDN2) |
| Short name: |
Claudin 2 Antibody (CLDN2) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Claudin 2 (Antibody to) (claudin 2) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CLDN2 and IDBG-647507 and ENSBTAG00000005290 and 404089, CLDN2 and IDBG-81294 and ENSG00000165376 and 9075, Cell surfaces, Cldn2 and IDBG-174401 and ENSMUSG00000047230 and 12738, identical protein binding, this GO :0005198 and structural molecule activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005923 and tight junction and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016338 and calcium-independent cell-cell adhesion and biological process this GO :0042802 and identical protein binding and molecular function this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0005198 : structural molecule activity, this GO :0005198 : structural molecule activity and also this GO :0005515 : protein binding and also this GO :0042802 : identical protein binding, this GO :0005515 : protein binding, this GO :0042802 : identical protein binding, claudin 2 |
| Identity: |
2041 |
| Gene: |
CLDN2 |
More about : CLDN2 |
| Long gene name: |
claudin 2 |
| Locus: |
Xq22, 3 |
| Discovery year: |
1998-11-19 |
| GenBank acession: |
AK075405 |
| Entrez gene record: |
9075 |
| Pubmed identfication: |
9892664 |
| Classification: |
Claudins |
| Havana BLAST/BLAT: |
OTTHUMG00000022154 |
| Locus Specific Databases: |
Mental Retardation database |