| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Claudin 1 (CLDN1) [Loop 2] |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the Claudin 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This Claudin 1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O95832 |
| Purity: |
Purified |
| Description: |
CLDN1 acts as a coreceptor for HCV entry into hepatic cells, CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin, Often, Required for normal water homeostasis and to prevent excessive water loss through the skin, While some claudin family members play essential roles in the formation of impermeable barriers, [UniProt], and this determines the overall permeability, others mediate the permeability to ions and small molecules, probably via an indirect effect on the expression levels of other proteins, several claudin family members are coexpressed and interact with each other, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions, Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia |
| Immunogen: |
A portion of amino acids 122-163 from the human protein (loop 2) was used as the immunogen for this Claudin 1 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the Claudin 1 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Claudin 1 (CLDN1) [Loop 2] |
| Short name: |
Claudin 1 Antibody (CLDN1) [Loop 2] |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Claudin 1 (Antibody to) (claudin 1) [Loop 2] |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CLD1 and ILVASC and SEMP1, CLDN1 and IDBG-634518 and ENSBTAG00000013148 and 414922, CLDN1 and IDBG-69639 and ENSG00000163347 and 9076, Cell surfaces, Cldn1 and IDBG-150373 and ENSMUSG00000022512 and 12737, identical protein binding, this GO :0005198 and structural molecule activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0005923 and tight junction and cellular component this GO :0007155 and cell adhesion and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0016032 and viral process and biological process this GO :0016324 and apical plasma membrane and cellular component this GO :0016328 and lateral plasma membrane and cellular component this GO :0016338 and calcium-independent cell-cell adhesion and biological process this GO :0042802 and identical protein binding and molecular function this GO :0045216 and cell-cell junction organization and biological process this GO :0061436 and establishment of skin barrier and biological process, this GO :0005198 : structural molecule activity, this GO :0005198 : structural molecule activity and also this GO :0005515 : protein binding and also this GO :0042802 : identical protein binding, this GO :0005515 : protein binding, this GO :0042802 : identical protein binding, claudin 1 |
| Identity: |
2032 |
| Gene: |
CLDN1 |
More about : CLDN1 |
| Long gene name: |
claudin 1 |
| Synonyms: |
SEMP1 ILVASC |
| Synonyms name: |
senescence-associated epithelial membrane protein 1 |
| Locus: |
3q28 |
| Discovery year: |
1998-11-19 |
| GenBank acession: |
AF101051 |
| Entrez gene record: |
9076 |
| Pubmed identfication: |
10828592 9892664 |
| RefSeq identity: |
NM_021101 |
| Classification: |
Claudins |
| Havana BLAST/BLAT: |
OTTHUMG00000156214 |