| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Claudin 1 (CLDN1) [Loop 1] |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IHC, WB |
| Recommended dilutions: |
IHC (Paraffin): 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the Claudin 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This Claudin 1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O95832 |
| Purity: |
Purified |
| Description: |
CLDN1, Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome, These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, a member of the claudin family, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space, is an integral membrane protein and a component of tight junction strands, with complementary grooves in the inwardly facing extracytoplasmic leaflet, Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets |
| Immunogen: |
A portion of amino acids 40-82 from the human protein (loop 1) was used as the immunogen for this Claudin 1 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the Claudin 1 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Claudin 1 (CLDN1) [Loop 1] |
| Short name: |
Claudin 1 Antibody (CLDN1) [Loop 1] |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Claudin 1 (Antibody to) (claudin 1) [Loop 1] |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CLD1 and ILVASC and SEMP1, CLDN1 and IDBG-634518 and ENSBTAG00000013148 and 414922, CLDN1 and IDBG-69639 and ENSG00000163347 and 9076, Cell surfaces, Cldn1 and IDBG-150373 and ENSMUSG00000022512 and 12737, identical protein binding, this GO :0005198 and structural molecule activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0005923 and tight junction and cellular component this GO :0007155 and cell adhesion and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0016032 and viral process and biological process this GO :0016324 and apical plasma membrane and cellular component this GO :0016328 and lateral plasma membrane and cellular component this GO :0016338 and calcium-independent cell-cell adhesion and biological process this GO :0042802 and identical protein binding and molecular function this GO :0045216 and cell-cell junction organization and biological process this GO :0061436 and establishment of skin barrier and biological process, this GO :0005198 : structural molecule activity, this GO :0005198 : structural molecule activity and also this GO :0005515 : protein binding and also this GO :0042802 : identical protein binding, this GO :0005515 : protein binding, this GO :0042802 : identical protein binding, claudin 1 |
| Identity: |
2032 |
| Gene: |
CLDN1 |
More about : CLDN1 |
| Long gene name: |
claudin 1 |
| Synonyms: |
SEMP1 ILVASC |
| Synonyms name: |
senescence-associated epithelial membrane protein 1 |
| Locus: |
3q28 |
| Discovery year: |
1998-11-19 |
| GenBank acession: |
AF101051 |
| Entrez gene record: |
9076 |
| Pubmed identfication: |
10828592 9892664 |
| RefSeq identity: |
NM_021101 |
| Classification: |
Claudins |
| Havana BLAST/BLAT: |
OTTHUMG00000156214 |