| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
HES1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IF, WB, FACS |
| Recommended dilutions: |
Flow Cytometry: 1:10-1:50, Immunofluorescence: 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the HES1 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This HES1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q14469 |
| Purity: |
Purified |
| Description: |
HES1 has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box, It is a transcriptional repressor of genes that require a bHLH protein for their transcription, HES1 belongs to the basic helix-loop-helix family of transcription factors |
| Immunogen: |
A portion of amino acids 9-38 from the human protein was used as the immunogen for this HES1 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the HES1 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
HES1 |
| Short name: |
HES1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
(Drosophila) (Antibody to), hairy and enhancer on split 1 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
(Drosophila), DNA-templated and biological process this GO :0006357 and regulation of transcription from RNA polymerase II promoter and biological process this GO :0006366 and transcription from RNA polymerase II promoter and biological process this GO :0006461 and protein complex assembly and biological process this GO :0007155 and cell adhesion and biological process this GO :0007219 and Notch signaling pathway and biological process this GO :0007224 and smoothened signaling pathway and biological process this GO :0007262 and STAT protein import into nucleus and biological process this GO :0007389 and pattern specification process and biological process this GO :0007399 and nervous system development and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0016477 and cell migration and biological process this GO :0021537 and telencephalon development and biological process this GO :0021555 and midbrain-hindbrain boundary morphogenesis and biological process this GO :0021557 and oculomotor nerve development and biological process this GO :0021558 and trochlear nerve development and biological process this GO :0021575 and hindbrain morphogenesis and biological process this GO :0021861 and forebrain radial glial cell differentiation and biological process this GO :0021915 and neural tube development and biological process this GO :0021983 and pituitary gland development and biological process this GO :0021984 and adenohypophysis development and biological process this GO :0030324 and lung development and biological process this GO :0030513 and positive regulation of BMP signaling pathway and biological process this GO :0030901 and midbrain development and biological process this GO :0031016 and pancreas development and biological process this GO :0031018 and endocrine pancreas development and biological process this GO :0035019 and somatic stem cell maintenance and biological process this GO :0035909 and aorta morphogenesis and biological process this GO :0035910 and ascending aorta morphogenesis and biological process this GO :0042102 and positive regulation of T cell proliferation and biological process this GO :0042491 and auditory receptor cell differentiation and biological process this GO :0042517 and positive regulation of tyrosine phosphorylation of Stat3 protein and biological process this GO :0042668 and auditory receptor cell fate determination and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0042826 and histone deacetylase binding and molecular function this GO :0043388 and positive regulation of DNA binding and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0045165 and cell fate commitment and biological process this GO :0045596 and negative regulation of cell differentiation and biological process this GO :0045598 and regulation of fat cell differentiation and biological process this GO :0045608 and negative regulation of auditory receptor cell differentiation and biological process this GO :0045665 and negative regulation of neuron differentiation and biological process this GO :0045747 and positive regulation of Notch signaling pathway and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0045977 and positive regulation of mitotic cell cycle, HES1 and IDBG-634294 and ENSBTAG00000000569 and 539547, HES1 and IDBG-70185 and ENSG00000114315 and 3280, Hes1 and IDBG-151888 and ENSMUSG00000022528 and 15205, N-box binding, bHLHb39 and HES-1 and HHL and HRY, embryonic and biological process this GO :0046331 and lateral inhibition and biological process this GO :0046427 and positive regulation of JAK-STAT cascade and biological process this GO :0046983 and protein dimerization activity and molecular function this GO :0048469 and cell maturation and biological process this GO :0048505 and regulation of timing of cell differentiation and biological process this GO :0048538 and thymus development and biological process this GO :0048667 and cell morphogenesis involved in neuron differentiation and biological process this GO :0048711 and positive regulation of astrocyte differentiation and biological process this GO :0048715 and negative regulation of oli this GO dendrocyte differentiation and biological process this GO :0048844 and artery morphogenesis and biological process this GO :0050767 and regulation of neurogenesis and biological process this GO :0060164 and regulation of timing of neuron differentiation and biological process this GO :0060253 and negative regulation of glial cell proliferation and biological process this GO :0060412 and ventricular septum morphogenesis and biological process this GO :0060675 and ureteric bud morphogenesis and biological process this GO :0060716 and labyrinthine layer blood vessel development and biological process this GO :0061009 and common bile duct development and biological process this GO :0061106 and negative regulation of stomach neuroendocrine cell differentiation and biological process this GO :0061309 and cardiac neural crest cell development involved in outflow tract morphogenesis and biological process this GO :0061626 and pharyngeal arch artery morphogenesis and biological process this GO :0071820 and N-box binding and molecular function this GO :0072012 and glomerulus vasculature development and biological process this GO :0072049 and comma-shaped body morphogenesis and biological process this GO :0072050 and S-shaped body morphogenesis and biological process this GO :0072141 and renal interstitial cell development and biological process this GO :0072282 and metanephric nephron tubule morphogenesis and biological process this GO :0090102 and cochlea development and biological process this GO :0097084 and vascular smooth muscle cell development and biological process this GO :0097150 and neuronal stem cell maintenance and biological process this GO :2000227 and negative regulation of pancreatic A cell differentiation and biological process this GO :2000737 and negative regulation of stem cell differentiation and biological process this GO :2000974 and negative regulation of pro-B cell differentiation and biological process this GO :2000978 and negative regulation of forebrain neuron differentiation and biological process this GO :2000981 and negative regulation of inner ear receptor cell differentiation and biological process, nuclei, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000981 and sequence-specific DNA binding RNA polymerase II transcription factor activity and molecular function this GO :0001078 and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription and molecular function this GO :0001701 and in utero embryonic development and biological process this GO :0001889 and liver development and biological process this GO :0003143 and embryonic heart tube morphogenesis and biological process this GO :0003151 and outflow tract morphogenesis and biological process this GO :0003266 and regulation of secondary heart field cardioblast proliferation and biological process this GO :0003281 and ventricular septum development and biological process this GO :0003677 and DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006355 and regulation of transcription, this GO :0000981 : sequence-specific DNA binding RNA polymerase II transcription factor activity, this GO :0000981 : sequence-specific DNA binding RNA polymerase II transcription factor activity and also this GO :0001078 : RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription and also this GO :0003677 : DNA binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0005515 : protein binding and also this GO :0008134 : transcription factor binding and also this GO :0042803 : protein homodimerization activity and also this GO :0042826 : histone deacetylase binding and also this GO :0043565 : sequence-specific DNA binding and also this GO :0046983 : protein dimerization activity and also this GO :0071820 : N-box binding, this GO :0001078 : RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription, this GO :0003677 : DNA binding, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0005515 : protein binding, this GO :0008134 : transcription factor binding, this GO :0042803 : protein homodimerization activity, this GO :0042826 : histone deacetylase binding, this GO :0043565 : sequence-specific DNA binding, this GO :0046983 : protein dimerization activity, this GO :0071820 : N-box binding, hairy and enhancer of split 1 |
| Identity: |
5192 |
| Gene: |
HES1 |
More about : HES1 |
| Long gene name: |
hes family bHLH transcription factor 1 |
| Synonyms gene: |
HRY |
| Synonyms gene name: |
(Drosophila) , hairy homolog (Drosophila) hairy and enhancer of split 1 |
| Synonyms: |
FLJ20408 HES-1 Hes1 bHLHb39 |
| Locus: |
3q29 |
| Discovery year: |
1993-09-21 |
| GenBank acession: |
L19314 |
| Entrez gene record: |
3280 |
| Pubmed identfication: |
8020957 |
| Classification: |
Basic helix-loop-helix proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000155984 |