| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
HAS2 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, FACS, IHC, WB |
| Recommended dilutions: |
Flow Cytometry: 1:10-1:50, IHC (Paraffin): 1:25-1:100, Western blot: 1:1000 |
| Notes: |
Titration of the HAS2 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This HAS2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q92819 |
| Purity: |
Antigen affinity |
| Description: |
Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis, HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts, HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, In addition, It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds, It serves a variety of functions, and human and murine hyaluronan synthase 1, and is a constituent of the extracellular matrix, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and overexpression of HA receptors has been correlated with tumor metastasis, and provision of a matrix through which cells can migrate, and the chains are extruded through pore-like structures into the extracellular space, including space filling, lubrication of joints, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals |
| Immunogen: |
A portion of amino acids 138-166 from the human protein was used as the immunogen for this HAS2 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the HAS2 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
HAS2 |
| Short name: |
HAS2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
HAS2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
4819 |
| Gene: |
HAS2 |
More about : HAS2 |
| Long gene name: |
hyaluronan synthase 2 |
| Locus: |
8q24, 13 |
| Discovery year: |
1996-10-18 |
| GenBank acession: |
U54804 |
| Entrez gene record: |
3037 |
| Pubmed identfication: |
9169154 |
| RefSeq identity: |
NM_005328 |
| Classification: |
Glycosyltransferase family 2 |
| Havana BLAST/BLAT: |
OTTHUMG00000164953 |