| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
TSC2 (phospho-S1365) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Mouse (Mus musculus) |
| Tested applications: |
ELISA, DB |
| Recommended dilutions: |
Dot blot: 1:500 |
| Notes: |
Titration of the phospho-TSC2 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This phospho-TSC2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q61037 |
| Purity: |
Antigen affinity |
| Description: |
Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, Implicated as a tumor suppressor, Involved in microtubule-mediated protein transport, Specifically stimulates the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5, Suggesting a possible mechanism for its role in regulating cellular growth (By similarity), a direct activator of the protein kinase activity of mTORC1, but this seems to be due to unregulated mTOR signaling (By similarity), inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling, In complex with TSC1 |
| Immunogen: |
This phospho-TSC2 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS1365 of mouse TSC2 |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the phospho-TSC2 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
TSC2 (phospho-S1365) |
| Short name: |
TSC2 Antibody (phospho-S1365) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
tuberous sclerosis 2 (Antibody to) (phosphorilated-S1365) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
14-3-3 protein binding, LAM and PPP1R160 and TSC4, TSC2 and IDBG-635000 and ENSBTAG00000020617 and 504985, TSC2 and IDBG-9819 and ENSG00000103197 and 7249, Tsc2 and IDBG-147651 and ENSMUSG00000002496 and 22084, nuclei, this GO :0001666 and response to hypoxia and biological process this GO :0001843 and neural tube closure and biological process this GO :0005096 and GTPase activator activity and molecular function this GO :0005488 and binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005829 and cytosol and cellular component this GO :0005856 and cytoskeleton and cellular component this GO :0005901 and caveola and cellular component this GO :0006469 and negative regulation of protein kinase activity and biological process this GO :0006606 and protein import into nucleus and biological process this GO :0006897 and endocytosis and biological process this GO :0006953 and acute-phase response and biological process this GO :0007050 and cell cycle arrest and biological process this GO :0007165 and signal transduction and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007507 and heart development and biological process this GO :0008104 and protein localization and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0008286 and insulin receptor signaling pathway and biological process this GO :0008543 and fibroblast growth factor receptor signaling pathway and biological process this GO :0014065 and phosphatidylinositol 3-kinase signaling and biological process this GO :0014067 and negative regulation of phosphatidylinositol 3-kinase signaling and biological process this GO :0016020 and membrane and cellular component this GO :0016192 and vesicle-mediated transport and biological process this GO :0019902 and phosphatase binding and molecular function this GO :0030030 and cell projection organization and biological process this GO :0030100 and regulation of endocytosis and biological process this GO :0030178 and negative regulation of Wnt signaling pathway and biological process this GO :0030425 and dendrite and cellular component this GO :0030426 and growth cone and cellular component this GO :0032007 and negative regulation of TOR signaling and biological process this GO :0032320 and positive regulation of Ras GTPase activity and biological process this GO :0033596 and TSC1-TSC2 complex and cellular component this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0043005 and neuron projection and cellular component this GO :0043025 and neuronal cell body and cellular component this GO :0043231 and intracellular membrane-bounded organelle and cellular component this GO :0043234 and protein complex and cellular component this GO :0043407 and negative regulation of MAP kinase activity and biological process this GO :0043491 and protein kinase B signaling and biological process this GO :0043547 and positive regulation of GTPase activity and biological process this GO :0045087 and innate immune response and biological process this GO :0045121 and membrane raft and cellular component this GO :0045184 and establishment of protein localization and biological process this GO :0045792 and negative regulation of cell size and biological process this GO :0046626 and regulation of insulin receptor signaling pathway and biological process this GO :0046627 and negative regulation of insulin receptor signaling pathway and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0048009 and insulin-like growth factor receptor signaling pathway and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0050680 and negative regulation of epithelial cell proliferation and biological process this GO :0050918 and positive chemotaxis and biological process this GO :0051056 and regulation of small GTPase mediated signal transduction and biological process this GO :0051260 and protein homooli this GO merization and biological process this GO :0051291 and protein heterooli this GO merization and biological process this GO :0051726 and regulation of cell cycle and biological process this GO :0051898 and negative regulation of protein kinase B signaling and biological process this GO :0071889 and 14-3-3 protein binding and molecular function, this GO :0005096 : GTPase activator activity, this GO :0005096 : GTPase activator activity and also this GO :0005488 : binding and also this GO :0005515 : protein binding and also this GO :0019902 : phosphatase binding and also this GO :0042803 : protein homodimerization activity and also this GO :0046982 : protein heterodimerization activity and also this GO :0071889 : 14-3-3 protein binding, this GO :0005488 : binding, this GO :0005515 : protein binding, this GO :0019902 : phosphatase binding, this GO :0042803 : protein homodimerization activity, this GO :0046982 : protein heterodimerization activity, this GO :0071889 : 14-3-3 protein binding, tuberous sclerosis 2 |
| Identity: |
12363 |
| Gene: |
TSC2 |
More about : TSC2 |
| Long gene name: |
tuberous sclerosis 2 |
| Synonyms gene: |
TSC4 |
| Synonyms: |
tuberin LAM PPP1R160 |
| Synonyms name: |
protein phosphatase 1, regulatory subunit 160 |
| Locus: |
16p13, 3 |
| Discovery year: |
1989-05-25 |
| GenBank acession: |
AB014460 |
| Entrez gene record: |
7249 |
| Pubmed identfication: |
1303246 7558029 |
| RefSeq identity: |
NM_000548 |
| Classification: |
Protein phosphatase 1 regulatory subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000128745 |
| Locus Specific Databases: |
TSC2 Mutation Database Tuberous sclerosis database LRG_487 |