| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Phospho-TSC1 (pS312) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Mouse (Mus musculus) |
| Tested applications: |
ELISA, DB |
| Recommended dilutions: |
Dot blot: 1:500 |
| Notes: |
Titration of the phospho-TSC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This phospho-TSC1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q9EP53 |
| Purity: |
Antigen affinity |
| Description: |
Implicated as a tumor suppressor, Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity), inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity), In complex with TSC2 |
| Immunogen: |
This phospho-TSC1 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS312 of mouse TSC1 |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the phospho-TSC1 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Phospho-TSC1 (pS312) |
| Short name: |
Phospho-TSC1 Antibody (pS312) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
phosphorilated-TSC1 (Antibody to) (pS312) |
| Alternative technique: |
antibodies |
| Identity: |
12362 |
| Gene: |
TSC1 |
More about : TSC1 |
| Long gene name: |
tuberous sclerosis 1 |
| Synonyms gene: |
TSC |
| Synonyms: |
KIAA0243 LAM hamartin |
| Locus: |
9q34 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
AF013168 |
| Pubmed identfication: |
9242607 10806479 |
| Havana BLAST/BLAT: |
OTTHUMG00000020844 |
| Locus Specific Databases: |
TSC Mutation Database Tuberous sclerosis database LRG_486 |