| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
p-SOX2 (pS83) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, DB |
| Recommended dilutions: |
Dot blot: 1:500 |
| Notes: |
Titration of the p-SOX2 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This p-SOX2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P48431 |
| Purity: |
Antigen affinity |
| Description: |
Mutations in the SOX2 gene have been associated with bilateral anophthalmia, This protein may act as a transcriptional activator after forming a protein complex with other proteins, a severe form of structural eye malformation, SOX2 is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate |
| Immunogen: |
This p-SOX2 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS83 of human SOX2 |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the p-SOX2 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
p-SOX2 (pS83) |
| Short name: |
p-SOX2 Antibody (pS83) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
p-SRY (sex determining region Y)-box 2 (Antibody to) (pS83) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ANOP3 and MCOPS3, DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006357 and regulation of transcription from RNA polymerase II promoter and biological process this GO :0006366 and transcription from RNA polymerase II promoter and biological process this GO :0007050 and cell cycle arrest and biological process this GO :0007605 and sensory perception of sound and biological process this GO :0009611 and response to wounding and biological process this GO :0010033 and response to organic substance and biological process this GO :0010468 and regulation of gene expression and biological process this GO :0019827 and stem cell maintenance and biological process this GO :0021781 and glial cell fate commitment and biological process this GO :0021879 and forebrain neuron differentiation and biological process this GO :0021983 and pituitary gland development and biological process this GO :0021984 and adenohypophysis development and biological process this GO :0021987 and cerebral cortex development and biological process this GO :0022409 and positive regulation of cell-cell adhesion and biological process this GO :0030178 and negative regulation of Wnt signaling pathway and biological process this GO :0030539 and male genitalia development and biological process this GO :0030858 and positive regulation of epithelial cell differentiation and biological process this GO :0030900 and forebrain development and biological process this GO :0030910 and olfactory placode formation and biological process this GO :0032526 and response to retinoic acid and biological process this GO :0035019 and somatic stem cell maintenance and biological process this GO :0035198 and miRNA binding and molecular function this GO :0042246 and tissue regeneration and biological process this GO :0042472 and inner ear morphogenesis and biological process this GO :0043281 and regulation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0043410 and positive regulation of MAPK cascade and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0043586 and tongue development and biological process this GO :0044212 and transcription regulatory region DNA binding and molecular function this GO :0044798 and nuclear transcription factor complex and cellular component this GO :0045165 and cell fate commitment and biological process this GO :0045596 and negative regulation of cell differentiation and biological process this GO :0045597 and positive regulation of cell differentiation and biological process this GO :0045665 and negative regulation of neuron differentiation and biological process this GO :0045666 and positive regulation of neuron differentiation and biological process this GO :0045668 and negative regulation of osteoblast differentiation and biological process this GO :0045747 and positive regulation of Notch signaling pathway and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046148 and pigment biosynthetic process and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0048286 and lung alveolus development and biological process this GO :0048568 and embryonic organ development and biological process this GO :0048646 and anatomical structure formation involved in morphogenesis and biological process this GO :0048663 and neuron fate commitment and biological process this GO :0048839 and inner ear development and biological process this GO :0048852 and diencephalon morphogenesis and biological process this GO :0048863 and stem cell differentiation and biological process this GO :0050680 and negative regulation of epithelial cell proliferation and biological process this GO :0050767 and regulation of neurogenesis and biological process this GO :0050910 and detection of mechanical stimulus involved in sensory perception of sound and biological process this GO :0050973 and detection of mechanical stimulus involved in equilibrioception and biological process this GO :0060042 and retina morphogenesis in camera-type eye and biological process this GO :0060235 and lens induction in camera-type eye and biological process this GO :0060441 and epithelial tube branching involved in lung morphogenesis and biological process this GO :0070848 and response to growth factor and biological process this GO :0090090 and negative regulation of canonical Wnt signaling pathway and biological process this GO :0097150 and neuronal stem cell maintenance and biological process, SOX2 and IDBG-647279 and ENSBTAG00000011598 and 784383, SOX2 and IDBG-66692 and ENSG00000181449 and 6657, Sox2 and IDBG-137912 and ENSMUSG00000074637 and 20674, nuclei, protein heterodimerization activity, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000976 and transcription regulatory region sequence-specific DNA binding and molecular function this GO :0000981 and sequence-specific DNA binding RNA polymerase II transcription factor activity and molecular function this GO :0001077 and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription and molecular function this GO :0001649 and osteoblast differentiation and biological process this GO :0001654 and eye development and biological process this GO :0001708 and cell fate specification and biological process this GO :0001714 and endodermal cell fate specification and biological process this GO :0002052 and positive regulation of neuroblast proliferation and biological process this GO :0003677 and DNA binding and molecular function this GO :0003682 and chromatin binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005667 and transcription factor complex and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006325 and chromatin organization and biological process this GO :0006351 and transcription, this GO :0000976 : transcription regulatory region sequence-specific DNA binding, this GO :0000976 : transcription regulatory region sequence-specific DNA binding and also this GO :0000981 : sequence-specific DNA binding RNA polymerase II transcription factor activity and also this GO :0001077 : RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription and also this GO :0003677 : DNA binding and also this GO :0003682 : chromatin binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0005515 : protein binding and also this GO :0035198 : miRNA binding and also this GO :0043565 : sequence-specific DNA binding and also this GO :0044212 : transcription regulatory region DNA binding and also this GO :0046982 : protein heterodimerization activity, this GO :0000981 : sequence-specific DNA binding RNA polymerase II transcription factor activity, this GO :0001077 : RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription, this GO :0003677 : DNA binding, this GO :0003682 : chromatin binding, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0005515 : protein binding, this GO :0035198 : miRNA binding, this GO :0043565 : sequence-specific DNA binding, this GO :0044212 : transcription regulatory region DNA binding, this GO :0046982 : protein heterodimerization activity, SRY (sex determining region Y)-box 2 |
| Identity: |
11195 |
| Gene: |
SOX2 |
More about : SOX2 |
| Long gene name: |
SRY-box 2 |
| Synonyms gene name: |
SRY (sex determining region Y)-box 2 SRY box 2 |
| Locus: |
3q26, 33 |
| Discovery year: |
1993-11-30 |
| GenBank acession: |
BC013923 |
| Entrez gene record: |
6657 |
| Pubmed identfication: |
7849401 |
| RefSeq identity: |
NM_003106 |
| Classification: |
SRY-boxes |
| Havana BLAST/BLAT: |
OTTHUMG00000158222 |
| Locus Specific Databases: |
LOVD LRG_719 |