| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
p-ErbB2 (pY1248) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
DB, ELISA, WB |
| Recommended dilutions: |
Dot blot: 1:500, Western blot: 1:8000 |
| Notes: |
Titration of the p-ErbB2 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This p-ErbB2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P04626 |
| Purity: |
Antigen affinity |
| Description: |
Amplification and/or overexpression of this gene has been reported in numerous cancers, However, This protein has no ligand binding domain of its own and therefore cannot bind growth factors, including breast and ovarian tumors, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase, ErbB2 is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases |
| Immunogen: |
This p-ErbB2 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pY1248 of human HER2/ErbB2 |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the p-ErbB2 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
p-ErbB2 (pY1248) |
| Short name: |
p-ErbB2 Antibody (pY1248) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
neuro/glioblastoma derived oncogene homolog (avian) (Antibody to) (pY1248), p-v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 |
| Alternative technique: |
antibodies |