| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
IRF8 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, FACS, WB |
| Recommended dilutions: |
Flow Cytometry: 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the IRF8 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This IRF8 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q02556 |
| Purity: |
Purified |
| Description: |
IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection, Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain, The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta, Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family |
| Immunogen: |
A portion of amino acids 241-269 from the human protein was used as the immunogen for this IRF8 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the IRF8 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
IRF8 |
| Short name: |
IRF8 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
interferon regulatory factor 8 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DNA-templated and biological process this GO :0006366 and transcription from RNA polymerase II promoter and biological process this GO :0006909 and pha this GO cytosis and biological process this GO :0006955 and immune response and biological process this GO :0009617 and response to bacterium and biological process this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0030099 and myeloid cell differentiation and biological process this GO :0032729 and positive regulation of interferon-gamma production and biological process this GO :0032735 and positive regulation of interleukin-12 production and biological process this GO :0042742 and defense response to bacterium and biological process this GO :0042832 and defense response to protozoan and biological process this GO :0044130 and negative regulation of growth of symbiont in host and biological process this GO :0045087 and innate immune response and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0060261 and positive regulation of transcription initiation from RNA polymerase II promoter and biological process this GO :0060333 and interferon-gamma-mediated signaling pathway and biological process this GO :0060337 and type I interferon signaling pathway and biological process this GO :0071222 and cellular response to lipopolysaccharide and biological process, H-ICSBP and ICSBP and ICSBP1 and IMD32A and IMD32B and IRF-8, IRF8 and IDBG-45278 and ENSG00000140968 and 3394, IRF8 and IDBG-630167 and ENSBTAG00000017824 and 614909, Irf8 and IDBG-196509 and ENSMUSG00000041515 and 15900, nuclei, protein binding, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000975 and regulatory region DNA binding and molecular function this GO :0003677 and DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0003705 and RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005829 and cytosol and cellular component this GO :0006355 and regulation of transcription, this GO :0000975 : regulatory region DNA binding, this GO :0000975 : regulatory region DNA binding and also this GO :0003677 : DNA binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0003705 : RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity and also this GO :0005515 : protein binding, this GO :0003677 : DNA binding, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0003705 : RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity, this GO :0005515 : protein binding, interferon regulatory factor 8 |
| Identity: |
5358 |
| Gene: |
IRF8 |
More about : IRF8 |
| Long gene name: |
interferon regulatory factor 8 |
| Synonyms gene: |
ICSBP1 |
| Synonyms gene name: |
interferon consensus sequence binding protein 1 |
| Synonyms: |
IRF-8 ICSBP |
| Locus: |
16q24, 1 |
| Discovery year: |
1993-09-09 |
| GenBank acession: |
M91196 |
| Entrez gene record: |
3394 |
| Pubmed identfication: |
1460054 11997525 |
| RefSeq identity: |
NM_002163 |
| Havana BLAST/BLAT: |
OTTHUMG00000137648 |
| Locus Specific Databases: |
LRG_294 |