| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
PROX1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the PROX1 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This PROX1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q92786 |
| Purity: |
Antigen affinity |
| Description: |
Cells lacking Prox1 are less likely to stop dividing, Consequently, Homozygous Prox1-null mice die at midgestation from multiple developmental defects, Loss of Prox1 results in a smaller liver with a reduced population of clustered hepatocytes, Prox mRNA is present in many different human tissues with lens demonstrating the highest level, Prox1 acts as a key participant in progenitor-cell proliferation and cell-fate determination in the vertebrate retina, Prox1 also has been documented to be required for hepatocyte migration in the mouse, Prox1 appears to be a specific and required regulator of the development of the lymphatic system, Prox1 inactivation caused abnormal cellular proliferation, Prox1 is expressed in a subpopulation of endothelial cells that by budding and sprouting give rise to the lymphatic system, The homeodomain protein Prox1 regulates the egress of progenitor cells from the cell cycle in the embryonic mouse retina, and a targeted effect on lens development has been reported, and ectopic expression of Prox1 forces progenitor cells to exit the cell cycle, and excessive apoptosis, downregulated expression of the cell cycle inhibitors Cdkn1b and Cdkn1c, including lens, misexpression of E-cadherin, mutant lens cells failed to polarize and elongate properly, resulting in a hollow lens, The expression pattern of Prox1 suggests that it has a role in a variety of embryonic tissues |
| Immunogen: |
A portion of amino acids 175-206 from the human protein was used as the immunogen for this PROX1 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the PROX1 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
PROX1 |
| Short name: |
PROX1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
prospero homeobox 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046619 and optic placode formation involved in camera-type eye formation and biological process this GO :0048839 and inner ear development and biological process this GO :0048845 and venous blood vessel morphogenesis and biological process this GO :0050692 and DBD domain binding and molecular function this GO :0050693 and LBD domain binding and molecular function this GO :0055005 and ventricular cardiac myofibril assembly and biological process this GO :0055009 and atrial cardiac muscle tissue morphogenesis and biological process this GO :0055010 and ventricular cardiac muscle tissue morphogenesis and biological process this GO :0060042 and retina morphogenesis in camera-type eye and biological process this GO :0060059 and embryonic retina morphogenesis in camera-type eye and biological process this GO :0060214 and endocardium formation and biological process this GO :0060298 and positive regulation of sarcomere organization and biological process this GO :0060412 and ventricular septum morphogenesis and biological process this GO :0060414 and aorta smooth muscle tissue morphogenesis and biological process this GO :0060421 and positive regulation of heart growth and biological process this GO :0060836 and lymphatic endothelial cell differentiation and biological process this GO :0060849 and regulation of transcription involved in lymphatic endothelial cell fate commitment and biological process this GO :0070309 and lens fiber cell morphogenesis and biological process this GO :0070365 and hepatocyte differentiation and biological process this GO :0070858 and negative regulation of bile acid biosynthetic process and biological process this GO :0072574 and hepatocyte proliferation and biological process this GO :0097150 and neuronal stem cell maintenance and biological process this GO :1901978 and positive regulation of cell cycle checkpoint and biological process this GO :2000179 and positive regulation of neural precursor cell proliferation and biological process this GO :2000979 and positive regulation of forebrain neuron differentiation and biological process, LBD domain binding, PROX1 and IDBG-106631 and ENSG00000117707 and 5629, PROX1 and IDBG-638014 and ENSBTAG00000010978 and 515324, Prox1 and IDBG-208536 and ENSMUSG00000010175 and 19130, nuclei, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000981 and sequence-specific DNA binding RNA polymerase II transcription factor activity and molecular function this GO :0001709 and cell fate determination and biological process this GO :0001822 and kidney development and biological process this GO :0001889 and liver development and biological process this GO :0001938 and positive regulation of endothelial cell proliferation and biological process this GO :0001945 and lymph vessel development and biological process this GO :0001946 and lymphangiogenesis and biological process this GO :0002088 and lens development in camera-type eye and biological process this GO :0002089 and lens morphogenesis in camera-type eye and biological process this GO :0002194 and hepatocyte cell migration and biological process this GO :0003677 and DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0003705 and RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity and molecular function this GO :0003714 and transcription corepressor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006366 and transcription from RNA polymerase II promoter and biological process this GO :0007420 and brain development and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0010468 and regulation of gene expression and biological process this GO :0010595 and positive regulation of endothelial cell migration and biological process this GO :0016922 and ligand-dependent nuclear receptor binding and molecular function this GO :0021516 and dorsal spinal cord development and biological process this GO :0021542 and dentate gyrus development and biological process this GO :0021707 and cerebellar granule cell differentiation and biological process this GO :0021915 and neural tube development and biological process this GO :0030240 and skeletal muscle thin filament assembly and biological process this GO :0030324 and lung development and biological process this GO :0030910 and olfactory placode formation and biological process this GO :0031016 and pancreas development and biological process this GO :0031667 and response to nutrient levels and biological process this GO :0043049 and otic placode formation and biological process this GO :0043433 and negative regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0044212 and transcription regulatory region DNA binding and molecular function this GO :0045071 and negative regulation of viral genome replication and biological process this GO :0045446 and endothelial cell differentiation and biological process this GO :0045737 and positive regulation of cyclin-dependent protein serine/threonine kinase activity and biological process this GO :0045787 and positive regulation of cell cycle and biological process this GO :0045892 and negative regulation of transcription, this GO :0000981 : sequence-specific DNA binding RNA polymerase II transcription factor activity, this GO :0000981 : sequence-specific DNA binding RNA polymerase II transcription factor activity and also this GO :0003677 : DNA binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0003705 : RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity and also this GO :0003714 : transcription corepressor activity and also this GO :0005515 : protein binding and also this GO :0016922 : ligand-dependent nuclear receptor binding and also this GO :0043565 : sequence-specific DNA binding and also this GO :0044212 : transcription regulatory region DNA binding and also this GO :0050692 : DBD domain binding and also this GO :0050693 : LBD domain binding, this GO :0003677 : DNA binding, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0003705 : RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity, this GO :0003714 : transcription corepressor activity, this GO :0005515 : protein binding, this GO :0016922 : ligand-dependent nuclear receptor binding, this GO :0043565 : sequence-specific DNA binding, this GO :0044212 : transcription regulatory region DNA binding, this GO :0050692 : DBD domain binding, this GO :0050693 : LBD domain binding, prospero homeobox 1 |
| Identity: |
9459 |
| Gene: |
PROX1 |
More about : PROX1 |
| Long gene name: |
prospero homeobox 1 |
| Synonyms gene name: |
prospero-related homeobox 1 |
| Locus: |
1q32, 3 |
| Discovery year: |
1998-05-18 |
| GenBank acession: |
U44060 |
| Entrez gene record: |
5629 |
| Pubmed identfication: |
8812486 |
| RefSeq identity: |
NM_002763 |
| Classification: |
PROS class homeoboxes |
| Havana BLAST/BLAT: |
OTTHUMG00000036946 |