| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Ips-1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Mouse (Mus musculus) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the Ips-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This Ips-1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q8VCF0 |
| Purity: |
Antigen affinity |
| Description: |
Acts downstream of DDX58 and IFIH1/MDA5, IRF3 and IRF7, May activate the same pathways following detection of extracellular dsRNA by TLR3, May protect cells from apoptosis (By similarity), and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5), to coordinate pathways leading to the activation of NF-kappa-B, which detect intracellular dsRNA produced during viral replication, Required for innate immune defense against viruses |
| Immunogen: |
A portion of amino acids 1-30 from the mouse protein was used as the immunogen for this Ips-1 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the Ips-1 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Ips-1 |
| Short name: |
Ips-1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Ips-1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
29233 |
| Gene: |
MAVS |
More about : MAVS |
| Long gene name: |
mitochondrial antiviral signaling protein |
| Synonyms: |
VISA KIAA1271 IPS-1 Cardif |
| Synonyms name: |
virus-induced signaling adaptor IFN-B promoter stimulator 1 CARD adaptor inducing IFN-beta |
| Locus: |
20p13 |
| Discovery year: |
2009-04-01 |
| GenBank acession: |
DQ174270 |
| Entrez gene record: |
57506 |
| Pubmed identfication: |
16125763 16153868 |
| RefSeq identity: |
NM_020746 |
| Classification: |
Caspase recruitment domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000031765 |