| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
ASCL1 (Achaete-scute homolog 1) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the ASCL1 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This ASCL1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P50553 |
| Purity: |
Antigen affinity |
| Description: |
Dimerization with other BHLH proteins is required for efficient DNA binding, Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases, The protein activates transcription by binding to the E box (5'-CANNTG-3'), This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons, a member of the basic helix-loop-helix (BHLH) family of transcription factors, This gene encodes 'Achaete scute complex homolog like 1' (ASCL1) or 'Mammalian achaete scute complex homolog 1' (MASH1) |
| Immunogen: |
A portion of amino acids 63-90 from the human protein was used as the immunogen for this MASH1 / ASCL1 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the ASCL1 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
ASCL1 (Achaete-scute homolog 1) |
| Short name: |
ASCL1 Antibody (Achaete-scute homolog 1) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
achaete-scute complex homolog 1 (Drosophila) (Antibody to) (Achaete-scute homolog 1) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ASCL1 and IDBG-53767 and ENSG00000139352 and 429, ASCL1 and IDBG-648540 and ENSBTAG00000016227 and 540473, ASH1 and bHLHa46 and HASH1 and MASH1, Ascl1 and IDBG-182849 and ENSMUSG00000020052 and 17172, DNA-templated and biological process this GO :0006357 and regulation of transcription from RNA polymerase II promoter and biological process this GO :0007219 and Notch signaling pathway and biological process this GO :0007346 and regulation of mitotic cell cycle and biological process this GO :0007389 and pattern specification process and biological process this GO :0007399 and nervous system development and biological process this GO :0007400 and neuroblast fate determination and biological process this GO :0007405 and neuroblast proliferation and biological process this GO :0008593 and regulation of Notch signaling pathway and biological process this GO :0010001 and glial cell differentiation and biological process this GO :0010226 and response to lithium ion and biological process this GO :0010468 and regulation of gene expression and biological process this GO :0014003 and oli this GO dendrocyte development and biological process this GO :0021527 and spinal cord association neuron differentiation and biological process this GO :0021529 and spinal cord oli this GO dendrocyte cell differentiation and biological process this GO :0021530 and spinal cord oli this GO dendrocyte cell fate specification and biological process this GO :0021750 and vestibular nucleus development and biological process this GO :0021779 and oli this GO dendrocyte cell fate commitment and biological process this GO :0021879 and forebrain neuron differentiation and biological process this GO :0021892 and cerebral cortex GABAergic interneuron differentiation and biological process this GO :0021902 and commitment of neuronal cell to specific neuron type in forebrain and biological process this GO :0021954 and central nervous system neuron development and biological process this GO :0021987 and cerebral cortex development and biological process this GO :0022008 and neurogenesis and biological process this GO :0030154 and cell differentiation and biological process this GO :0030182 and neuron differentiation and biological process this GO :0030856 and regulation of epithelial cell differentiation and biological process this GO :0032526 and response to retinoic acid and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0043025 and neuronal cell body and cellular component this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043425 and bHLH transcription factor binding and molecular function this GO :0043525 and positive regulation of neuron apoptotic process and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0045665 and negative regulation of neuron differentiation and biological process this GO :0045666 and positive regulation of neuron differentiation and biological process this GO :0045747 and positive regulation of Notch signaling pathway and biological process this GO :0045787 and positive regulation of cell cycle and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046983 and protein dimerization activity and molecular function this GO :0048469 and cell maturation and biological process this GO :0048485 and sympathetic nervous system development and biological process this GO :0048663 and neuron fate commitment and biological process this GO :0048665 and neuron fate specification and biological process this GO :0048666 and neuron development and biological process this GO :0048699 and generation of neurons and biological process this GO :0048709 and oli this GO dendrocyte differentiation and biological process this GO :0050767 and regulation of neurogenesis and biological process this GO :0050769 and positive regulation of neurogenesis and biological process this GO :0050883 and musculoskeletal movement, E-box binding, nuclei, spinal reflex action and biological process this GO :0051593 and response to folic acid and biological process this GO :0060163 and subpallium neuron fate commitment and biological process this GO :0060165 and regulation of timing of subpallium neuron differentiation and biological process this GO :0060166 and olfactory pit development and biological process this GO :0060487 and lung epithelial cell differentiation and biological process this GO :0060579 and ventral spinal cord interneuron fate commitment and biological process this GO :0061100 and lung neuroendocrine cell differentiation and biological process this GO :0061102 and stomach neuroendocrine cell differentiation and biological process this GO :0061103 and carotid body glomus cell differentiation and biological process this GO :0061104 and adrenal chromaffin cell differentiation and biological process this GO :0061549 and sympathetic ganglion development and biological process this GO :0070849 and response to epidermal growth factor and biological process this GO :0070888 and E-box binding and molecular function this GO :0071259 and cellular response to magnetism and biological process this GO :2000179 and positive regulation of neural precursor cell proliferation and biological process, this GO :0000989 and transcription factor binding transcription factor activity and molecular function this GO :0001764 and neuron migration and biological process this GO :0003358 and noradrenergic neuron development and biological process this GO :0003359 and noradrenergic neuron fate commitment and biological process this GO :0003677 and DNA binding and molecular function this GO :0003682 and chromatin binding and molecular function this GO :0003690 and double-stranded DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0006351 and transcription, this GO :0000989 : transcription factor binding transcription factor activity, this GO :0000989 : transcription factor binding transcription factor activity and also this GO :0003677 : DNA binding and also this GO :0003682 : chromatin binding and also this GO :0003690 : double-stranded DNA binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0005515 : protein binding and also this GO :0042803 : protein homodimerization activity and also this GO :0043425 : bHLH transcription factor binding and also this GO :0043565 : sequence-specific DNA binding and also this GO :0046983 : protein dimerization activity and also this GO :0070888 : E-box binding, this GO :0003677 : DNA binding, this GO :0003682 : chromatin binding, this GO :0003690 : double-stranded DNA binding, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0005515 : protein binding, this GO :0042803 : protein homodimerization activity, this GO :0043425 : bHLH transcription factor binding, this GO :0043565 : sequence-specific DNA binding, this GO :0046983 : protein dimerization activity, this GO :0070888 : E-box binding, achaete-scute complex homolog 1 (Drosophila) |
| Identity: |
738 |
| Gene: |
ASCL1 |
More about : ASCL1 |
| Long gene name: |
achaete-scute family bHLH transcription factor 1 |
| Synonyms gene name: |
achaete-scute complex (Drosophila) homolog-like 1 achaete-scute complex-like 1 (Drosophila) achaete-scute complex homolog 1 (Drosophila) |
| Synonyms: |
ASH1 HASH1 bHLHa46 |
| Locus: |
12q23, 2 |
| Discovery year: |
1993-12-09 |
| GenBank acession: |
L08424 |
| Entrez gene record: |
429 |
| Pubmed identfication: |
8390674 |
| Classification: |
Basic helix-loop-helix proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000169967 |