| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
TFE3 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the TFE3 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This TFE3 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P19532 |
| Purity: |
Antigen affinity |
| Description: |
NonO (p54nrb)-TFE3 and ASPL-TFE3, PSF-TFE3, RCC17-TFE3, SMAD3, TFE3, TFEB and TFEC, The TEF3 protein encoded by this gene activates transcription through binding to the muE3 motif of the immunoglobulin heavy-chain enhancer, The TEF3 protein interacts with transcription regulators such as E2F3, The TFE3 protein also activates hepatic IRS-2 gene, The TFEC protein forms heterodimers with the TEF3 protein and inhibits TFE3-dependent transcription activation, This gene is also involved in chromosomal translocations, and LEF-1, and induces hexokinase II (HK2) and insulin-induced gene 1 (INSIG1), and is involved in TGF-beta-induced transcription, and osteoclast and macrophage differentiation, it participates in insulin signaling and could be a therapeutic target for diabetes, playing important roles in cell growth, proliferation, resulting in different fusion gene products in papillary renal cell carcinomas and alveolar soft part sarcomas, such as PRCC-TFE3, The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF |
| Immunogen: |
A portion of amino acids 489-516 from the human protein was used as the immunogen for this TFE3 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the TFE3 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
TFE3 |
| Short name: |
TFE3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TFE3 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11752 |
| Gene: |
TFE3 |
More about : TFE3 |
| Long gene name: |
transcription factor binding to IGHM enhancer 3 |
| Synonyms: |
TFEA bHLHe33 |
| Synonyms name: |
transcription factor E family member A |
| Locus: |
Xp11, 23 |
| Discovery year: |
1990-10-16 |
| GenBank acession: |
X96717 |
| Entrez gene record: |
7030 |
| Pubmed identfication: |
1672758 1685140 |
| RefSeq identity: |
NM_006521 |
| Classification: |
Basic helix-loop-helix proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000022690 |
| Locus Specific Databases: |
Mental Retardation database |