| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Integrin beta 2 (ITGB2) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the Integrin beta 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This Integrin beta 2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P05107 |
| Purity: |
Antigen affinity |
| Description: |
A given chain may combine with multiple partners resulting in different integrins, Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1), For example, Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain, Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling, This gene encodes the integrin beta chain beta 2, Two transcript variants encoding the same protein have been identified for this gene, and combines with the alpha M chain to form the integrin Mac-1, beta 2 combines with the alpha L chain to form the integrin LFA-1, The product of this gene belongs to the integrin beta chain family of proteins |
| Immunogen: |
This Integrin beta 2 antibody was produced from rabbits immunized with a recombinant protein from the human ITGB2 |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the Integrin beta 2 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Integrin beta 2 (ITGB2) |
| Short name: |
Integrin beta 2 Antibody (ITGB2) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
b 2 (complement component 3 receptor 3 and 4 subunit)), Integrin b 2 (Antibody to) (integrin |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CD18 and LAD and LCAMB and LFA-1 and MAC-1 and MF17 and MFI7, Cell surfaces, ITGB2 and IDBG-5590 and ENSG00000160255 and 3689, ITGB2 and IDBG-639611 and ENSBTAG00000017060 and 281877, beta 2 (complement component 3 receptor 3 and 4 subunit), metal ion binding, this GO :0001948 and glycoprotein binding and molecular function this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0004872 and receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0006915 and apoptotic process and biological process this GO :0006954 and inflammatory response and biological process this GO :0007155 and cell adhesion and biological process this GO :0007159 and leukocyte cell-cell adhesion and biological process this GO :0007160 and cell-matrix adhesion and biological process this GO :0007229 and integrin-mediated signaling pathway and biological process this GO :0007267 and cell-cell signaling and biological process this GO :0007275 and multicellular organismal development and biological process this GO :0007596 and blood coagulation and biological process this GO :0008305 and integrin complex and cellular component this GO :0008360 and regulation of cell shape and biological process this GO :0009986 and cell surface and cellular component this GO :0016020 and membrane and cellular component this GO :0019901 and protein kinase binding and molecular function this GO :0030198 and extracellular matrix organization and biological process this GO :0030593 and neutrophil chemotaxis and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0043235 and receptor complex and cellular component this GO :0045087 and innate immune response and biological process this GO :0046872 and metal ion binding and molecular function this GO :0050730 and regulation of peptidyl-tyrosine phosphorylation and biological process this GO :0050776 and regulation of immune response and biological process this GO :0050900 and leukocyte migration and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0001948 : glycoprotein binding, this GO :0001948 : glycoprotein binding and also this GO :0004872 : receptor activity and also this GO :0005515 : protein binding and also this GO :0019901 : protein kinase binding and also this GO :0046872 : metal ion binding, this GO :0004872 : receptor activity, this GO :0005515 : protein binding, this GO :0019901 : protein kinase binding, this GO :0046872 : metal ion binding, integrin |
| Identity: |
6155 |
| Gene: |
ITGB2 |
More about : ITGB2 |
| Long gene name: |
integrin subunit beta 2 |
| Synonyms gene: |
CD18 MFI7 |
| Synonyms gene name: |
beta 2 (antigen CD18 (p95), beta 2 (complement component 3 receptor 3 and 4 subunit) , integrin, lymphocyte function-associated antigen 1, macrophage antigen 1 (mac-1) beta subunit) integrin |
| Synonyms: |
LFA-1 MAC-1 |
| Synonyms name: |
complement component 3 receptor 3 and 4 subunit |
| Locus: |
21q22, 3 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
AK222505 |
| Entrez gene record: |
3689 |
| RefSeq identity: |
NM_000211 |
| Classification: |
Complement system Integrin beta subunits CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000090257 |
| Locus Specific Databases: |
ITGB2base: Mutation registry for Leukocyte adhesion deficiency I (LAD-I) LRG_76 |