| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Prostate-Specific Membrane Antigen (PSMA) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IHC, WB, IF |
| Recommended dilutions: |
IHC (Paraffin): 1:10-1:50, Immunofluorescence: 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the PSMA antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This PSMA antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q04609 |
| Purity: |
Antigen affinity |
| Description: |
All of which refer to the same protein, GCPII is a class II membrane glycoprotein, In cancer, In human prostate cancer, It catalyzes the hydrolysis of N-acetylaspartylglutamate (NAAG) to glutamate and N-acetylaspartate (NAA), Most of the enzyme resides in the extracellular space, Neuroscientists primarily use the term NAALADase in their studies, PSMA, PSMA is strongly expressed in the human prostate, [Wiki], and those studying prostate cancer or oncology, being a hundredfold greater than the expression in most other tissues, glutamate carboxypeptidase II, it is upregulated in expression and has been called the second-most-upregulated gene in prostate cancer, the higher expressing tumors are associated with quicker time to progression and a greater percentage of patients suffering relapse, while those studying folate metabolism use folate hydrolase, with increase of 8- to 12-fold over the noncancerous prostate, GCPII is a zinc metalloenzyme that resides in membranes |
| Immunogen: |
A portion of amino acids 161-190 from the human protein was used as the immunogen for this PSMA antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the PSMA antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Prostate-Specific Membrane (PSMA) |
| Short name: |
Prostate-Specific Membrane Antigen Antibody (PSMA) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Prostate-Specific Membrane protein (Antibody to) (PSMA) |
| Alternative technique: |
antibodies |
| Identity: |
3788 |
| Gene: |
FOLH1 |
More about : FOLH1 |
| Long gene name: |
folate hydrolase 1 |
| Synonyms gene: |
FOLH |
| Synonyms gene name: |
folate hydrolase (prostate-specific membrane antigen) 1 |
| Synonyms: |
PSM PSMA NAALAD1 NAALAdase GCP2 GCPII |
| Synonyms name: |
glutamate carboxylase II glutamate carboxypeptidase 2 |
| Locus: |
11p11, 12 |
| Discovery year: |
1996-12-16 |
| GenBank acession: |
M99487 |
| Entrez gene record: |
2346 |
| Pubmed identfication: |
9838072 |
| RefSeq identity: |
NM_004476 |
| Havana BLAST/BLAT: |
OTTHUMG00000166625 |