| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
BNIP3 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IHC, WB, IF |
| Recommended dilutions: |
IHC (Paraffin): 1:50-1:100, Immunofluorescence: 1:50-1:100, Western blot: 1:1000 |
| Notes: |
Titration of the BNIP3 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This BNIP3 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q12983 |
| Purity: |
Purified |
| Description: |
It interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, NIP3 contains a BH3 domain and a transmembrane domain, The dimeric mitochondrial protein is known to induce apoptosis, also an apoptotic protector, as well as E1B 19 kDa-like sequences of BCL2, even in the presence of BCL2, which have been associated with pro-apoptotic function, NIP3 is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family |
| Immunogen: |
A portion of amino acids 152-187 from the human protein (BH3 domain) was used as the immunogen for this BNIP3 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the BNIP3 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
BNIP3 |
| Short name: |
BNIP3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
B-cell CLL/lymphoma 2/adenovirus E1B 19kDa interacting protein 3 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BNIP3 and IDBG-641206 and ENSBTAG00000017804 and 615342, BNIP3 and IDBG-93314 and ENSG00000176171 and 664, Bnip3 and IDBG-269444 and ENSMUSG00000078566 and 12176, GTPase binding, NIP3, nuclei, this GO :0001666 and response to hypoxia and biological process this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005635 and nuclear envelope and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005740 and mitochondrial envelope and cellular component this GO :0005741 and mitochondrial outer membrane and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0006915 and apoptotic process and biological process this GO :0008219 and cell death and biological process this GO :0008626 and granzyme-mediated apoptotic signaling pathway and biological process this GO :0010508 and positive regulation of autophagy and biological process this GO :0010637 and negative regulation of mitochondrial fusion and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0016032 and viral process and biological process this GO :0030425 and dendrite and cellular component this GO :0031307 and integral component of mitochondrial outer membrane and cellular component this GO :0031966 and mitochondrial membrane and cellular component this GO :0035694 and mitochondrial protein catabolic process and biological process this GO :0042802 and identical protein binding and molecular function this GO :0042803 and protein homodimerization activity and molecular function this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043068 and positive regulation of programmed cell death and biological process this GO :0043243 and positive regulation of protein complex disassembly and biological process this GO :0043653 and mitochondrial fragmentation involved in apoptotic process and biological process this GO :0045837 and negative regulation of membrane potential and biological process this GO :0046902 and regulation of mitochondrial membrane permeability and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0048102 and autophagic cell death and biological process this GO :0050873 and brown fat cell differentiation and biological process this GO :0051020 and GTPase binding and molecular function this GO :0051402 and neuron apoptotic process and biological process this GO :0051607 and defense response to virus and biological process this GO :0055093 and response to hyperoxia and biological process this GO :0070301 and cellular response to hydrogen peroxide and biological process this GO :0071260 and cellular response to mechanical stimulus and biological process this GO :0071279 and cellular response to cobalt ion and biological process this GO :0071456 and cellular response to hypoxia and biological process this GO :0072593 and reactive oxygen species metabolic process and biological process this GO :0090141 and positive regulation of mitochondrial fission and biological process this GO :0090200 and positive regulation of release of cytochrome c from mitochondria and biological process this GO :0097193 and intrinsic apoptotic signaling pathway and biological process this GO :0097345 and mitochondrial outer membrane permeabilization and biological process this GO :1990144 and intrinsic apoptotic signaling pathway in response to hypoxia and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0042802 : identical protein binding and also this GO :0042803 : protein homodimerization activity and also this GO :0046982 : protein heterodimerization activity and also this GO :0051020 : GTPase binding, this GO :0042802 : identical protein binding, this GO :0042803 : protein homodimerization activity, this GO :0046982 : protein heterodimerization activity, this GO :0051020 : GTPase binding, BCL2/adenovirus E1B 19kDa interacting protein 3 |
| Identity: |
1084 |
| Gene: |
BNIP3 |
More about : BNIP3 |
| Long gene name: |
BCL2 interacting protein 3 |
| Synonyms gene name: |
BCL2/adenovirus E1B 19kDa interacting protein 3 |
| Synonyms: |
Nip3 |
| Locus: |
10q26, 3 |
| Discovery year: |
1997-03-19 |
| GenBank acession: |
U15174 |
| Entrez gene record: |
664 |
| Pubmed identfication: |
7954800 |
| Classification: |
BCL2 homology region 3 (BH3) only |
| Havana BLAST/BLAT: |
OTTHUMG00000019278 |