| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
SUMO4 (V55 Mutant) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IHC, WB |
| Recommended dilutions: |
IHC (Paraffin): 1:50-1:100, Western blot: 1:1000 |
| Notes: |
Titration of the SUMO4 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This SUMO4 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q6EEV6 |
| Purity: |
Purified |
| Description: |
Covalent attachment to SUMO4 substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, In contrast to SUMO1, SUMO2 and SUMO3, SUMO4 conjugates to various anti-oxidant enzymes, SUMO4 is located in the cytoplasm and specifically modifies IKBA, SUMO4 seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90, TFAP2A and FOS, The M55V substitution has been associated with type I diabetes, This family of small ubiquitin-related modifiers covalently modify target lysines in proteins and control the target proteins' subcellular localization, This may impair processing to mature form and conjugation to substrates, This protein may also conjugate to NFKBIA, Upon oxidative stress, and stress defense proteins, and to NR3C1, chaperones, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene, negatively regulating their transcriptional activity, or activity, positively regulating its transcriptional activity, stability, SUMO4 is a member of the SUMO gene family |
| Immunogen: |
This antibody is affinity purified using peptides CEPRGLS(V)KQIRFRFG (positive selection) and CEPRGLS(M)KQIRFRFG (negative selection), This SUMO4 antibody was produced from rabbits immunized with a KLH conjugated peptide CEPRGLS(V)KQIRFRFG selected from human SUMO4 |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the SUMO4 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
SUMO4 (V55 Mutant) |
| Short name: |
SUMO4 Antibody (V55 Mutant) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
SUMO4 (Antibody to) (V55 Mutant) |
| Alternative technique: |
antibodies |
| Identity: |
21181 |
| Gene: |
SUMO4 |
More about : SUMO4 |
| Long gene name: |
small ubiquitin-like modifier 4 |
| Synonyms gene: |
SMT3H4 IDDM5 |
| Synonyms gene name: |
SMT3 suppressor of mif two 3 homolog 4 (yeast) SMT3 suppressor of mif two 3 homolog 4 (S, cerevisiae) insulin-dependent diabetes mellitus 5 |
| Synonyms: |
dJ281H8, 4 |
| Locus: |
6q25, 1 |
| Discovery year: |
2003-11-27 |
| Entrez gene record: |
387082 |
| Pubmed identfication: |
15123604 |
| Havana BLAST/BLAT: |
OTTHUMG00000015785 |