GCLC Antibody

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Catalog number: F41799-0.4ML
Price: 406 €
Supplier: NJS poly
Product name: GCLC Antibody
Quantity: 0.4 ml
Other quantities: 0.08 ml 199€ 0.1mg 389€ 0.1ml 263€ 0.4 ml 406€ 1 vial 521€
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Category: Antibody
Concentration: pH 7, with 0, 09% sodium azide, 4, In 1X PBS
Form: Antigen affinity purified
Conjugation: Unconjugated
Clone: Polyclonal antibody
Recognised antigen: GCLC
Host animal: Rabbit (Oryctolagus cuniculus)
Clonality: Polyclonal (rabbit origin)
Species reactivity: Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications: ELISA, FACS, IF, IHC, WB
Recommended dilutions: Flow Cytometry: 1:10-1:50, IHC (Paraffin): 1:10-1:50, Immunofluorescence: 1:10-1:50, Western blot: 1:1000
Notes: Titration of the GCLC antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented use: This GCLC antibodyis to be used only for research purposes and not for diagnostics
Uniprot #: P48506
Purity: Antigen affinity
Description: Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction, The enzyme consists of two subunits, This locus encodes the catalytic subunit, a heavy catalytic subunit and a light regulatory subunit, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21, Glutamate-cysteine ligase
Immunogen: A portion of amino acids 1-30 from the human protein was used as the immunogen for this GCLC antibody
Storage: Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the GCLC antibody and store frozen at -20 deg
Properties: C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene target: GCLC
Short name: GCLC Antibody
Technique: antibodies against human proteins, antibodies for, Antibody
Alternative name: catalytic subunit (Antibody to), glutamate-cysteine ligase
Alternative technique: antibodies
Alternative to gene target: Cytoplasm, DNA-templated and biological process this GO :0046685 and response to arsenic-containing substance and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0050662 and coenzyme binding and molecular function this GO :0050880 and regulation of blood vessel size and biological process this GO :0051409 and response to nitrosative stress and biological process this GO :0051900 and regulation of mitochondrial depolarization and biological process this GO :1901687 and glutathione derivative biosynthetic process and biological process this GO :2001237 and negative regulation of extrinsic apoptotic signaling pathway and biological process, GCL and GCS and GLCL and GLCLC, GCLC and IDBG-628748 and ENSBTAG00000015571 and 512468, GCLC and IDBG-91041 and ENSG00000001084 and 102724876, Gclc and IDBG-186028 and ENSMUSG00000032350 and 14629, catalytic subunit, coenzyme binding, this GO :0000096 and sulfur amino acid metabolic process and biological process this GO :0000287 and magnesium ion binding and molecular function this GO :0004357 and glutamate-cysteine ligase activity and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006534 and cysteine metabolic process and biological process this GO :0006536 and glutamate metabolic process and biological process this GO :0006749 and glutathione metabolic process and biological process this GO :0006750 and glutathione biosynthetic process and biological process this GO :0006805 and xenobiotic metabolic process and biological process this GO :0006979 and response to oxidative stress and biological process this GO :0008637 and apoptotic mitochondrial changes and biological process this GO :0009408 and response to heat and biological process this GO :0009410 and response to xenobiotic stimulus and biological process this GO :0009725 and response to hormone and biological process this GO :0016595 and glutamate binding and molecular function this GO :0017109 and glutamate-cysteine ligase complex and cellular component this GO :0019852 and L-ascorbic acid metabolic process and biological process this GO :0031397 and negative regulation of protein ubiquitination and biological process this GO :0032436 and positive regulation of proteasomal ubiquitin-dependent protein catabolic process and biological process this GO :0034641 and cellular nitrogen compound metabolic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :0043531 and ADP binding and molecular function this GO :0044281 and small molecule metabolic process and biological process this GO :0045454 and cell redox homeostasis and biological process this GO :0045892 and negative regulation of transcription, this GO :0000287 : magnesium ion binding, this GO :0000287 : magnesium ion binding and also this GO :0004357 : glutamate-cysteine ligase activity and also this GO :0005524 : ATP binding and also this GO :0016595 : glutamate binding and also this GO :0043531 : ADP binding and also this GO :0046982 : protein heterodimerization activity and also this GO :0050662 : coenzyme binding, this GO :0004357 : glutamate-cysteine ligase activity, this GO :0005524 : ATP binding, this GO :0016595 : glutamate binding, this GO :0043531 : ADP binding, this GO :0046982 : protein heterodimerization activity, this GO :0050662 : coenzyme binding, 2729, glutamate-cysteine ligase
Identity: 4311
Gene: GCLC | More about : GCLC
Long gene name: glutamate-cysteine ligase catalytic subunit
Synonyms gene: GLCLC GLCL
Synonyms gene name: catalytic subunit , glutamate-cysteine ligase
Synonyms: GCS
Locus: 6p12, 1
Discovery year: 1993-11-24
GenBank acession: M90656
Entrez gene record: 2729
Pubmed identfication: 1350904
Havana BLAST/BLAT: OTTHUMG00000160220

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