| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
ADA |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB, FACS |
| Recommended dilutions: |
Flow Cytometry: 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the ADA antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This ADA antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P00813 |
| Purity: |
Antigen affinity |
| Description: |
Acts as a positive regulator of T-cell coactivation, Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion, Modulates signaling by extracellular adenosine, Plays an important role in purine metabolism and in adenosine homeostasis, [UniProt], and so contributes indirectly to cellular signaling events, by binding DPP4, Adenosine deaminase (ADA) catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine |
| Immunogen: |
A portion of amino acids 287-314 from the human protein was used as the immunogen for this ADA antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the ADA antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
ADA |
| Short name: |
ADA Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
adenosine deaminase (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ADA and IDBG-642808 and ENSBTAG00000005280 and 280712, ADA and IDBG-76830 and ENSG00000196839 and 100, Ada and IDBG-211962 and ENSMUSG00000017697 and 11486, Extracellular, deaminase activity, non-REM sleep and biological process this GO :0042493 and response to drug and biological process this GO :0042542 and response to hydrogen peroxide and biological process this GO :0043025 and neuronal cell body and cellular component this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043101 and purine-containing compound salvage and biological process this GO :0043103 and hypoxanthine salvage and biological process this GO :0043278 and response to morphine and biological process this GO :0044281 and small molecule metabolic process and biological process this GO :0045187 and regulation of circadian sleep/wake cycle, sleep and biological process this GO :0045580 and regulation of T cell differentiation and biological process this GO :0045582 and positive regulation of T cell differentiation and biological process this GO :0045987 and positive regulation of smooth muscle contraction and biological process this GO :0046061 and dATP catabolic process and biological process this GO :0046101 and hypoxanthine biosynthetic process and biological process this GO :0046103 and inosine biosynthetic process and biological process this GO :0046111 and xanthine biosynthetic process and biological process this GO :0046638 and positive regulation of alpha-beta T cell differentiation and biological process this GO :0048286 and lung alveolus development and biological process this GO :0048541 and Peyer's patch development and biological process this GO :0048566 and embryonic digestive tract development and biological process this GO :0050728 and negative regulation of inflammatory response and biological process this GO :0050850 and positive regulation of calcium-mediated signaling and biological process this GO :0050862 and positive regulation of T cell receptor signaling pathway and biological process this GO :0050870 and positive regulation of T cell activation and biological process this GO :0055086 and nucleobase-containing small molecule metabolic process and biological process this GO :0060169 and negative regulation of adenosine receptor signaling pathway and biological process this GO :0060205 and cytoplasmic membrane-bounded vesicle lumen and cellular component this GO :0060407 and negative regulation of penile erection and biological process this GO :0070244 and negative regulation of thymocyte apoptotic process and biological process this GO :0070256 and negative regulation of mucus secretion and biological process, this GO :0001666 and response to hypoxia and biological process this GO :0001701 and in utero embryonic development and biological process this GO :0001821 and histamine secretion and biological process this GO :0001829 and trophectodermal cell differentiation and biological process this GO :0001883 and purine nucleoside binding and molecular function this GO :0001889 and liver development and biological process this GO :0001890 and placenta development and biological process this GO :0002314 and germinal center B cell differentiation and biological process this GO :0002636 and positive regulation of germinal center formation and biological process this GO :0002686 and negative regulation of leukocyte migration and biological process this GO :0002906 and negative regulation of mature B cell apoptotic process and biological process this GO :0004000 and adenosine deaminase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005615 and extracellular space and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005764 and lysosome and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006144 and purine nucleobase metabolic process and biological process this GO :0006154 and adenosine catabolic process and biological process this GO :0006157 and deoxyadenosine catabolic process and biological process this GO :0007155 and cell adhesion and biological process this GO :0007568 and aging and biological process this GO :0008152 and metabolic process and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0009168 and purine ribonucleoside monophosphate biosynthetic process and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0009986 and cell surface and cellular component this GO :0010460 and positive regulation of heart rate and biological process this GO :0016020 and membrane and cellular component this GO :0019239 and deaminase activity and molecular function this GO :0030054 and cell junction and cellular component this GO :0030324 and lung development and biological process this GO :0030890 and positive regulation of B cell proliferation and biological process this GO :0032261 and purine nucleotide salvage and biological process this GO :0032839 and dendrite cytoplasm and cellular component this GO :0033089 and positive regulation of T cell differentiation in thymus and biological process this GO :0033197 and response to vitamin E and biological process this GO :0033632 and regulation of cell-cell adhesion mediated by integrin and biological process this GO :0042110 and T cell activation and biological process this GO :0042323 and negative regulation of circadian sleep/wake cycle, this GO :0001883 : purine nucleoside binding, this GO :0001883 : purine nucleoside binding and also this GO :0004000 : adenosine deaminase activity and also this GO :0005515 : protein binding and also this GO :0008270 : zinc ion binding and also this GO :0019239 : deaminase activity, this GO :0004000 : adenosine deaminase activity, this GO :0005515 : protein binding, this GO :0008270 : zinc ion binding, this GO :0019239 : deaminase activity, adenosine deaminase |
| Identity: |
186 |
| Gene: |
ADA |
More about : ADA |
| Long gene name: |
adenosine deaminase |
| Locus: |
20q13, 12 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
X02994 |
| Entrez gene record: |
100 |
| Pubmed identfication: |
6198240 6090454 |
| RefSeq identity: |
NM_000022 |
| Classification: |
Adenosine deaminase family |
| Havana BLAST/BLAT: |
OTTHUMG00000033081 |
| Locus Specific Databases: |
ADAbase: Mutation registry for Adenosine Deaminase Deficiency LRG_16 |