| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
COL1A2 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the COL1A2 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This COL1A2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P08123 |
| Purity: |
Antigen affinity |
| Description: |
Dalgleish], Ehlers-Danlos syndrome type VIIB, Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Symptoms associated with mutations in this gene, Three transcripts, Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, [provided by R, and atypical Marfan syndrome, cornea, dermis and tendon, have been identified for this gene, however, idiopathic osteoporosis, recessive Ehlers-Danlos syndrome Classical type, resulting from the use of alternate polyadenylation signals, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity, This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain |
| Immunogen: |
A portion of amino acids 16-43 from the human protein was used as the immunogen for this COL1A2 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the COL1A2 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
COL1A2 |
| Short name: |
COL1A2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
a 2 (Antibody to), classification I, collagen |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
COL1A2 and IDBG-27319 and ENSG00000164692 and 1278, COL1A2 and IDBG-629088 and ENSBTAG00000013472 and 282188, Col1a2 and IDBG-127903 and ENSMUSG00000029661 and 12843, Extracellular, OI4, alpha 2, bridging, bridging and also this GO :0042802 : identical protein binding and also this GO :0046332 : SMAD binding and also this GO :0046872 : metal ion binding and also this GO :0048407 : platelet-derived growth factor binding, bridging and molecular function this GO :0031012 and extracellular matrix and cellular component this GO :0042476 and odontogenesis and biological process this GO :0042802 and identical protein binding and molecular function this GO :0043589 and skin morphogenesis and biological process this GO :0046332 and SMAD binding and molecular function this GO :0046872 and metal ion binding and molecular function this GO :0048407 and platelet-derived growth factor binding and molecular function this GO :0050900 and leukocyte migration and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0070208 and protein heterotrimerization and biological process this GO :0071230 and cellular response to amino acid stimulus and biological process, protein binding, this GO :0001501 and skeletal system development and biological process this GO :0001568 and blood vessel development and biological process this GO :0005201 and extracellular matrix structural constituent and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005581 and collagen trimer and cellular component this GO :0005584 and collagen type I and cellular component this GO :0005615 and extracellular space and cellular component this GO :0005788 and endoplasmic reticulum lumen and cellular component this GO :0007179 and transforming growth factor beta receptor signaling pathway and biological process this GO :0007266 and Rho protein signal transduction and biological process this GO :0007596 and blood coagulation and biological process this GO :0008217 and regulation of blood pressure and biological process this GO :0022617 and extracellular matrix disassembly and biological process this GO :0030168 and platelet activation and biological process this GO :0030198 and extracellular matrix organization and biological process this GO :0030199 and collagen fibril organization and biological process this GO :0030574 and collagen catabolic process and biological process this GO :0030674 and protein binding, this GO :0005201 : extracellular matrix structural constituent, this GO :0005201 : extracellular matrix structural constituent and also this GO :0005515 : protein binding and also this GO :0030674 : protein binding, this GO :0005515 : protein binding, this GO :0030674 : protein binding, this GO :0042802 : identical protein binding, this GO :0046332 : SMAD binding, this GO :0046872 : metal ion binding, this GO :0048407 : platelet-derived growth factor binding, type I, collagen |
| Identity: |
2198 |
| Gene: |
COL1A2 |
More about : COL1A2 |
| Long gene name: |
collagen type I alpha 2 chain |
| Synonyms gene: |
OI4 |
| Synonyms gene name: |
alpha 2 collagen type I alpha 2 , osteogenesis imperfecta type IV collagen, type I |
| Synonyms name: |
alpha 2(I)-collagen alpha-2 collagen type I type I procollagen collagen I, alpha-2 chain , alpha-2 polypeptide collagen of skin, tendon and bone |
| Locus: |
7q21, 3 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
Z74616 |
| Entrez gene record: |
1278 |
| Pubmed identfication: |
3857213 2897363 |
| RefSeq identity: |
NM_000089 |
| Classification: |
Collagens |
| Havana BLAST/BLAT: |
OTTHUMG00000148675 |
| Locus Specific Databases: |
Osteogenesis Imperfecta Variant Database LRG_2 |