| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
TNFR1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, FACS, WB |
| Recommended dilutions: |
Flow Cytometry: 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the TNFR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This TNFR1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P19438 |
| Purity: |
Antigen affinity |
| Description: |
Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome, The impaired receptor clearance is thought to be a mechanism of the disease, This protein is one of the major receptors for the tumor necrosis factor-alpha, This receptor can activate NF-kappaB, and function as a regulator of inflammation, and thus play regulatory roles in the signal transduction mediated by the receptor, mediate apoptosis, The protein encoded by this gene is a member of the TNF-receptor superfamily |
| Immunogen: |
A portion of amino acids 252-281 from the human protein was used as the immunogen for this TNFR1 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the TNFR1 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
TNFR1 |
| Short name: |
TNFR1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TNFR1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11916 |
| Gene: |
TNFRSF1A |
More about : TNFRSF1A |
| Long gene name: |
TNF receptor superfamily member 1A |
| Synonyms gene: |
TNFR1 |
| Synonyms gene name: |
member 1A , tumor necrosis factor receptor superfamily |
| Synonyms: |
TNF-R TNFAR TNFR60 TNF-R-I CD120a TNF-R55 |
| Locus: |
12p13, 31 |
| Discovery year: |
1991-01-15 |
| GenBank acession: |
M75866 |
| Entrez gene record: |
7132 |
| Pubmed identfication: |
1655358 2158863 |
| RefSeq identity: |
NM_001065 |
| Classification: |
CD molecules Tumor necrosis factor receptor superfamily |
| Havana BLAST/BLAT: |
OTTHUMG00000168267 |
| Locus Specific Databases: |
INFEVERS: The repertory of Familial Mediterranean Fever (FMF) and Hereditary Inflammatory Disorders Mutations LRG_193 |