| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
TNFR1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the TNFR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This TNFR1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P19438 |
| Purity: |
Antigen affinity |
| Description: |
Additionally, Complex I, ERK2) activation and arachidonic acid release, In a second step, Its gene is located on 12p13, MADD provides a physical link between TNFR1 and the induction of mitogen-activated protein(MAP) kinase(e, TNFR1 associates with the MADD protein through a death domain-death domain interaction, TNFR1-induced apoptosis involves 2 sequential signaling complexes, TRADD and RIP1 associate with FADD and caspase-8, The coding region and the 3-prime untranslated region of TNFR1 are distributed over 10 exons, There are 2 different proteins that serve as major receptors for TNF-alpha, a potent cytokine, and TRAF2 and rapidly signals activation of NF-kappa-B, complex II, consists of TNFR1, elicits a broad spectrum of biologic responses which are mediated by binding to a cell surface receptor, forming a cytoplasmic complex, one associated with myeloid cells and one associated with epithelial cells, the adaptor TRADD, the initial plasma membrane-bound complex, the kinase RIP1, 2, Tumor necrosis factor receptor 1(TNFR1), g |
| Immunogen: |
An amino acid sequence from the middle region of human TNF Receptor I (CLPQIENVKGTEDSGTT) |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the TNFR1 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
TNFR1 |
| Short name: |
TNFR1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TNFR1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11916 |
| Gene: |
TNFRSF1A |
More about : TNFRSF1A |
| Long gene name: |
TNF receptor superfamily member 1A |
| Synonyms gene: |
TNFR1 |
| Synonyms gene name: |
member 1A , tumor necrosis factor receptor superfamily |
| Synonyms: |
TNF-R TNFAR TNFR60 TNF-R-I CD120a TNF-R55 |
| Locus: |
12p13, 31 |
| Discovery year: |
1991-01-15 |
| GenBank acession: |
M75866 |
| Entrez gene record: |
7132 |
| Pubmed identfication: |
1655358 2158863 |
| RefSeq identity: |
NM_001065 |
| Classification: |
CD molecules Tumor necrosis factor receptor superfamily |
| Havana BLAST/BLAT: |
OTTHUMG00000168267 |
| Locus Specific Databases: |
INFEVERS: The repertory of Familial Mediterranean Fever (FMF) and Hereditary Inflammatory Disorders Mutations LRG_193 |