ETV5 Antibody

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Catalog number: F40893-0.4ML
Price: 406 €
Supplier: NJS poly
Product name: ETV5 Antibody
Quantity: 0.4 ml
Other quantities: 0.08 ml 199€ 0.1ml 263€ 0.4 ml 406€ 1 vial 486€ 100ug 370€ 100ul 486€
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Category: Antibody
Concentration: pH 7, with 0, 09% sodium azide, 4, In 1X PBS
Form: Antigen affinity purified
Conjugation: Unconjugated
Clone: Polyclonal antibody
Recognised antigen: ETV5
Host animal: Rabbit (Oryctolagus cuniculus)
Clonality: Polyclonal (rabbit origin)
Species reactivity: Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications: ELISA, WB, FACS
Recommended dilutions: Flow Cytometry: 1:10-1:50, Western blot: 1:1000
Notes: Titration of the ETV5 antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented use: This ETV5 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #: P41161
Purity: Antigen affinity
Description: All three members are 95% identical in the ETS domain and more than 85% in the acidic transactivation domain, Depending on the cellular context, Deregulated expression and/or formation of chimeric fusion proteins of the ETS family due to proviral insertion or chromosome translocation is associated with leukemias and with specific types of solid tumors, ERG, ERG, ETV4, ETV4 (also called PEA3) and ETV5 (also called ERM), ETV5 has been shown to act through matrix metalloproteinase-2 gelatinolytic activity to confer invasive capabilities, EWS, Ets proteins have been implicated in regulation of gene expression during a variety of biological processes, G-proteins, In nearly all Ewing?s sarcoma tumors, Indeed, It was shown that ETS signal transduction is implicated in hematopoiesis and angiogenesis at the earliest stages of embryogenesis, Several studies suggest that the PEA3 group proteins are involved in intestinal tumors, Signals regulating cell growth are transmitted from outside the cell to the nucleus by growth factors and their receptors, T-cell activation, The acquisition of a migratory phenotype by the epithelial tumor cells together with the remodeling of the extracellular matrix must accompany the process of cancer cell invasion, These findings suggest an important role for PEA3 proteins in prostate cancer, This results in the expression of chimeric proteins that may be important in tumor cell transformation, also called ER81), an AR-regulated gene, and ETV1, and breast cancer metastasis, and developmental programs in many organisms, and is later involved in tissue development, associated with an initial switch to myometrial infiltration, characterized by an evolutionarily conserved DNA-binding domain, gastric cancer, including FLI, including growth control, is fused by chromosomal translocation to an Ets gene, is fused by translocation to the ETV1, it was reported that TMPRSS2, kinases and transcription factors, or ETV4 gene in a subset of prostate cancers, regulates expression of more than 300 target genes by binding to a purine-rich GGAA/T core sequence, the PEA3 group consists of ETV1 (Ets variant gene 1, they can function as transactivators or transrepressors, transformation, which encodes a RNA-binding protein, 1 Among the multiple Ets proteins, 2 Recently, 3 In addition Ets family members have been correlated to tumor progression by upregulating the expression of matrix-degrading proteases, 4, The ETS family of transcription factors
Immunogen: A portion of amino acids 8-36 from the human protein was used as the immunogen for this ETV5 antibody
Storage: Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the ETV5 antibody and store frozen at -20 deg
Properties: C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene target: ETV5
Short name: ETV5 Antibody
Technique: antibodies against human proteins, antibodies for, Antibody
Alternative name: ETV5 (Antibody to)
Alternative technique: antibodies
Identity: 3494
Gene: ETV5 | More about : ETV5
Long gene name: ETS variant 5
Synonyms gene name: ets variant gene 5 (ets-related molecule)
Synonyms: ERM
Synonyms name: ets-related molecule
Locus: 3q27, 2
Discovery year: 1996-07-26
GenBank acession: BC007333
Entrez gene record: 2119
Pubmed identfication: 8152800
RefSeq identity: NM_004454
Classification: ETS transcription factor family
Havana BLAST/BLAT: OTTHUMG00000156639

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