| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
IL-12B |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, FACS, WB, IHC |
| Recommended dilutions: |
Flow Cytometry: 1:10-1:50, IHC (Paraffin): 1:50-1:100, Western blot: 1:1000 |
| Notes: |
Titration of the IL-12B antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This IL-12B antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P29460 |
| Purity: |
Antigen affinity |
| Description: |
Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children, This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen, This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development, a cytokine that acts on T and natural killer cells, and a 35 kD subunit encoded by IL12A, and has a broad array of biological activities, suggesting a role of this cytokine in the pathogenesis of the disease, IL12B is a subunit of interleukin 12 |
| Immunogen: |
A portion of amino acids 264-290 from the human protein was used as the immunogen for this IL-12B antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the IL-12B antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
IL-12B |
| Short name: |
IL-12B Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Interleukin-12B (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
5970 |
| Gene: |
IL12B |
More about : IL12B |
| Long gene name: |
interleukin 12B |
| Synonyms gene: |
NKSF2 |
| Synonyms gene name: |
cytotoxic lymphocyte maturation factor 2, interleukin 12B (natural killer cell stimulatory factor 2, p40) |
| Synonyms: |
CLMF IL-12B NKSF CLMF2 |
| Synonyms name: |
40 kD subunit interleukin-12 beta chain IL12, natural killer cell stimulatory factor-2 cytotoxic lymphocyte maturation factor 2, p40 interleukin 12, p40 natural killer cell stimulatory factor, subunit p40 |
| Locus: |
5q33, 3 |
| Discovery year: |
1991-08-08 |
| GenBank acession: |
M65290 |
| Entrez gene record: |
3593 |
| Pubmed identfication: |
1673147 |
| RefSeq identity: |
NM_002187 |
| Classification: |
Interleukins Immunoglobulin like domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000130307 |
| Locus Specific Databases: |
IL12Bbase: Mutation registry for Interleukin-12 (IL-12) p40 deficiency LRG_71 |