| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Dnmt3b |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IHC, WB |
| Recommended dilutions: |
IHC (Paraffin): 1:10-1:50, Western blot: 1:2000 |
| Notes: |
Titration of the Dnmt3b antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This Dnmt3b antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q9UBC3 |
| Purity: |
Purified |
| Description: |
Dnmt3b is a DNA methyltransferase which is thought to function in de novo methylation, Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF)syndrome, Studies in mice have demonstrated that DNA methylation is required for mammalian development, The protein localizes primarily to the nucleus and its expression is developmentally regulated, and X-chromosome inactivation, imprinting, rather than maintenance methylation, CpG methylation is an epigenetic modification that is important for embryonic development |
| Immunogen: |
A portion of amino acids 389-417 from the human protein was used as the immunogen for this Dnmt3b antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the Dnmt3b antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Dnmt3b |
| Short name: |
Dnmt3b Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Dnmt3b (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
2979 |
| Gene: |
DNMT3B |
More about : DNMT3B |
| Long gene name: |
DNA methyltransferase 3 beta |
| Synonyms gene name: |
DNA (cytosine-5-)-methyltransferase 3 beta |
| Locus: |
20q11, 21 |
| Discovery year: |
1998-07-15 |
| Entrez gene record: |
1789 |
| Pubmed identfication: |
9662389 10433969 |
| RefSeq identity: |
NM_006892 |
| Classification: |
PWWP domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000032226 |
| Locus Specific Databases: |
DNMT3Bbase: Mutation registry for ICF syndrome LRG_56 |