Dnmt1 Antibody

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Catalog number: F40597-0.4ML
Price: 406 €
Supplier: NJS poly
Product name: Dnmt1 Antibody
Quantity: 0.4 ml
Other quantities: 0.08 ml 199€ 0.1mg 406€ 0.1ml 263€ 0.4 ml 406€ 1 vial 532€ 1 x 1 vial 532€
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Category: Antibody
Concentration: pH 7, with 0, 09% sodium azide, 4, In 1X PBS
Form: Antigen affinity purified
Conjugation: Unconjugated
Clone: Polyclonal antibody
Recognised antigen: Dnmt1
Host animal: Rabbit (Oryctolagus cuniculus)
Clonality: Polyclonal (rabbit origin)
Species reactivity: Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications: ELISA, WB
Recommended dilutions: Western blot: 1:1000
Notes: Titration of the Dnmt1 antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented use: This Dnmt1 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #: P26358
Purity: Antigen affinity
Description: 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt1 also cooperates with Rb to repress transcription from promoters containing E2Fbinding sites suggesting a link between DNA methylation, Dnmt1 co-purifies with the retinoblastoma (Rb) tumour suppressor gene product, Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality, Dnmt2 and Dnmt3, Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation, Dnmt3a and Dnmt3b, E2F1, Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer, The Dnmt3 family members, To date, and HDAC1, are strongly expressed in ES cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue, as well as a growth-regulatory pathway that is disrupted in nearly all cancer cells, genomic imprinting and is essential for mammalian development, histone deacetylase and sequence-specific DNA binding activity, Methylation of DNA at cytosine residues plays an important role in regulation of gene expression
Immunogen: A portion of amino acids 1083-1112 from the human protein was used as the immunogen for this Dnmt1 antibody
Storage: Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the Dnmt1 antibody and store frozen at -20 deg
Properties: C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene target: Dnmt1
Short name: Dnmt1 Antibody
Technique: antibodies against human proteins, antibodies for, Antibody
Alternative name: Dnmt1 (Antibody to)
Alternative technique: antibodies
Identity: 2975
Gene: DNMT | More about : DNMT
Long gene name: DNA methyltransferase 1
Synonyms gene name: DNA (cytosine-5-)-methyltransferase 1
Synonyms: MCMT CXXC9 DNMT1
Locus: 19p13, 2
Discovery year: 1991-06-04
GenBank acession: X63692
Entrez gene record: 1786
Pubmed identfication: 1594447
RefSeq identity: NM_001379
Classification: Zinc fingers CXXC-type
Havana BLAST/BLAT: OTTHUMG00000180397
Locus Specific Databases: LRG_362

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