| Long name: |
Dnmt1 Primary Polyclonal Antibody |
| Also known as: |
Dnmt1 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Dnmt1 |
| Specificity: |
This antibody will not recongize isoform 3, This is a highly specific antibody against Dnmt1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
10-60/1616 |
| Subcellular location: |
Nucleus |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Dnmt1 |
| Gene ID number: |
1786 |
| Swiss Prot: |
P26358 |
| Tested Applications: |
IF(IHC-P), IHC-P |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication, DNA methylation is coordinated with methylation of histones, In association with DNMT3B and via the recruitment of CTCFL/BORIS, It is responsible for maintaining methylation patterns established in development, Mediates transcriptional repression by direct binding to HDAC2, Preferentially methylates hemimethylated DNA, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9, that is essential for epigenetic inheritance, Methylates CpG residues |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
ADCADN, CXXC-type zinc finger protein 9, CXXC9, DNA (cytosine-5)-methyltransferase 1, DNA MTase HsaI, DNA methyltransferase HsaI, DNMT, Dnmt1, HSN1E, M, MCMT, AIM, HsaI |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Dnmt1 |
| Short name: |
Dnmt1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Dnmt1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
2975 |
| Gene: |
DNMT |
More about : DNMT |
| Long gene name: |
DNA methyltransferase 1 |
| Synonyms gene name: |
DNA (cytosine-5-)-methyltransferase 1 |
| Synonyms: |
MCMT CXXC9 DNMT1 |
| Locus: |
19p13, 2 |
| Discovery year: |
1991-06-04 |
| GenBank acession: |
X63692 |
| Entrez gene record: |
1786 |
| Pubmed identfication: |
1594447 |
| RefSeq identity: |
NM_001379 |
| Classification: |
Zinc fingers CXXC-type |
| Havana BLAST/BLAT: |
OTTHUMG00000180397 |
| Locus Specific Databases: |
LRG_362 |