| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
STUB1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB, IHC |
| Recommended dilutions: |
IHC (Paraffin): 1:50-1:100, Western blot: 1:1000 |
| Notes: |
Titration of the STUB1 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This STUB1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q9UNE7 |
| Purity: |
Antigen affinity |
| Description: |
CHIP E3 controls both the association of Hsp70/Hsp90 chaperones with ErbB2 and the down-regulation of ErbB2 induced by inhibitors of Hsp90, CHIP can interact with the Smad1/Smad4 proteins and block BMP signal transduction through the ubiquitin-mediated degradation of Smad proteins, CHIP functions as a negative regulator of AR transcriptional activity by promoting AR degradation, CHIP is associated with Parkin and enhances its ubiquitin ligase activity related to Parkinson's disease, CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival, Co-chaperone CHIP, modulates the ubiquitylation of mutant Cu/Zn-superoxide dismutase and renders them more susceptible for proteasomal degradation, possibly with another E3 ligase(s), CHIP is an E3 ligase for nNOS whose action is facilitated by (and possibly requires) its interaction with nNOS-bound hsp70 |
| Immunogen: |
A portion of amino acids 203-231 from the human protein was used as the immunogen for this STUB1 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the STUB1 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
STUB1 |
| Short name: |
STUB1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
STUB1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11427 |
| Gene: |
STUB1 |
More about : STUB1 |
| Long gene name: |
STIP1 homology and U-box containing protein 1 |
| Synonyms gene name: |
E3 ubiquitin protein ligase , STIP1 homology and U-box containing protein 1 STIP1 homology and U-box containing protein 1 |
| Synonyms: |
UBOX1 CHIP SDCCAG7 HSPABP2 NY-CO-7 |
| Locus: |
16p13, 3 |
| Discovery year: |
1999-11-25 |
| GenBank acession: |
AF039689 |
| Entrez gene record: |
10273 |
| Pubmed identfication: |
10330192 9610721 |
| RefSeq identity: |
NM_005861 |
| Classification: |
Tetratricopeptide repeat domain containing U-box domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000121140 |