| Category: |
Antibody |
| Concentration: |
09% sodium azide, 4 with 0, In 1X PBS pH 7 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
SIGLEC7 (D-siglec) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IHC, WB |
| Recommended dilutions: |
IHC (Paraffin): 1:50-1:100, Western blot: 1:1000 |
| Notes: |
Titration of the SIGLEC7 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This SIGLEC7 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q9Y286 |
| Purity: |
Antigen affinity |
| Description: |
Also binds disialogangliosides (disialogalactosyl globoside, In the immune response, Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro), May play a role in hemopoiesis, Mediates inhibition of natural killer cells cytotoxicity, Preferentially binds to alpha-2, SIGLEC7 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells, The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface, [UniProt], disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide), may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules, 3- and alpha-2, 6-linked sialic acid, SIGLECs are cell surface proteins of the Ig superfamily |
| Immunogen: |
A portion of amino acids 407-438 from the human protein was used as the immunogen for this SIGLEC7 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the SIGLEC7 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
SIGLEC7 (D-siglec) |
| Short name: |
SIGLEC7 Antibody (D-siglec) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sialic acid binding Ig-like lectin 7 (Antibody to) (D-siglec) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Plasma membranes, SIGLEC7 and IDBG-65680 and ENSG00000168995 and 27036, carbohydrate binding, this GO :0004872 and receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005887 and integral component of plasma membrane and cellular component this GO :0007155 and cell adhesion and biological process this GO :0030246 and carbohydrate binding and molecular function this GO :0045087 and innate immune response and biological process, this GO :0004872 : receptor activity, this GO :0004872 : receptor activity and also this GO :0005515 : protein binding and also this GO :0030246 : carbohydrate binding, this GO :0005515 : protein binding, this GO :0030246 : carbohydrate binding, sialic acid binding Ig-like lectin 7 |
| Identity: |
10876 |
| Gene: |
SIGLEC7 |
More about : SIGLEC7 |
| Long gene name: |
sialic acid binding Ig like lectin 7 |
| Synonyms gene: |
SIGLEC19P SIGLECP2 |
| Synonyms gene name: |
pseudogene 2 sialic acid binding Ig-like lectin 7 , pseudogene sialic acid binding Ig-like lectin, sialic acid binding Ig-like lectin 19 |
| Synonyms: |
SIGLEC-7 p75/AIRM1 QA79 CD328 |
| Locus: |
19q13, 41 |
| Discovery year: |
2000-01-26 |
| GenBank acession: |
AF170485 |
| Entrez gene record: |
27036 |
| Pubmed identfication: |
10567377 |
| RefSeq identity: |
NM_016543 |
| Classification: |
CD molecules Sialic acid binding Ig like lectins V-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000182895 |