| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
HLA-DQA1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, FACS, WB |
| Recommended dilutions: |
Flow Cytometry: 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the HLA-DQA1 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This HLA-DQA1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P01909 |
| Purity: |
Antigen affinity |
| Description: |
Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, It is encoded by 5 exons, It plays a central role in the immune system by presenting peptides derived from extracellular proteins, The alpha chain is approximately 33-35 kDa, The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), Typing for these polymorphisms is routinely done for bone marrow transplantation, Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, and exon 4 encodes the transmembrane domain and the cytoplasmic tail, both anchored in the membrane, dendritic cells, exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, macrophages), resulting in up to four different molecules, HLA-DQA1 belongs to the HLA class II alpha chain paralogues |
| Immunogen: |
A portion of amino acids 39-66 from the human protein was used as the immunogen for this HLA-DQA1 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the HLA-DQA1 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
HLA-DQA1 |
| Short name: |
HLA-DQA1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
DQ a 1 (Antibody to), class II, major histocompatibility aggregate |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DQ alpha 1, HLA-DQA1 and IDBG-81099 and ENSG00000196735 and 100509457, Plasma membranes, class II, peptide antigen binding, this GO :0000139 and this GO lgi membrane and cellular component this GO :0002504 and antigen processing and presentation of peptide or polysaccharide antigen via MHC class II and biological process this GO :0005515 and protein binding and molecular function this GO :0005765 and lysosomal membrane and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006955 and immune response and biological process this GO :0010008 and endosome membrane and cellular component this GO :0012507 and ER to this GO lgi transport vesicle membrane and cellular component this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0019882 and antigen processing and presentation and biological process this GO :0019886 and antigen processing and presentation of exogenous peptide antigen via MHC class II and biological process this GO :0030658 and transport vesicle membrane and cellular component this GO :0030666 and endocytic vesicle membrane and cellular component this GO :0030669 and clathrin-coated endocytic vesicle membrane and cellular component this GO :0031295 and T cell costimulation and biological process this GO :0032395 and MHC class II receptor activity and molecular function this GO :0032588 and trans- this GO lgi network membrane and cellular component this GO :0042605 and peptide antigen binding and molecular function this GO :0042613 and MHC class II protein complex and cellular component this GO :0050852 and T cell receptor signaling pathway and biological process this GO :0060333 and interferon-gamma-mediated signaling pathway and biological process this GO :0071556 and integral component of lumenal side of endoplasmic reticulum membrane and cellular component, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0032395 : MHC class II receptor activity and also this GO :0042605 : peptide antigen binding, this GO :0032395 : MHC class II receptor activity, this GO :0042605 : peptide antigen binding, 3117, 102723931, 102724794, major histocompatibility complex |
| Identity: |
4942 |
| Gene: |
HLA-DQA1 |
More about : HLA-DQA1 |
| Long gene name: |
DQ alpha 1 , class II, major histocompatibility complex |
| Synonyms gene: |
HLA-DQA |
| Synonyms: |
CELIAC1 |
| Locus: |
6p21, 32 |
| Discovery year: |
2001-06-22 |
| Entrez gene record: |
3117 |
| RefSeq identity: |
NM_002122 |
| Classification: |
C1-set domain containing Histocompatibility complex |
| Havana BLAST/BLAT: |
OTTHUMG00000031106 |
| Locus Specific Databases: |
IMGT/HLA Database |