| Category: |
Antibody |
| Concentration: |
09% sodium azide, 4 with 0, In 1X PBS pH 7 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
TPSAB1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, FACS, WB |
| Recommended dilutions: |
Flow Cytometry: 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the TPSAB1 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This TPSAB1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q15661 |
| Purity: |
Antigen affinity |
| Description: |
Beta tryptases appear to be the main isoenzymes expressed in mast cells, Several tryptase genes are clustered on chromosome 16p13, The alleles of this gene exhibit an unusual amount of sequence variation, These genes are characterized by several distinct features, These genes have an intron immediately upstream of the initiator Met codon, They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability, This feature is characteristic of tryptases but is unusual in other genes, Tryptases are enzymatically active only as heparin-stabilized tetramers, Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders, alpha and beta 1, alpha tryptases predominate, and they are resistant to all known endogenous proteinase inhibitors, such that the alleles were once thought to represent two separate genes, the peptidase family S1, whereas in basophils, which separates the site of transcription initiation from protein coding sequence, 3, Tryptases comprise a family of trypsin-like serine proteases |
| Immunogen: |
A portion of amino acids 61-87 from the human protein was used as the immunogen for this TPSAB1 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the TPSAB1 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
TPSAB1 |
| Short name: |
TPSAB1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TPSAB1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
12019 |
| Gene: |
TPSAB1 |
More about : TPSAB1 |
| Long gene name: |
tryptase alpha/beta 1 |
| Synonyms gene: |
TPSB1 TPS1 TPS2 |
| Synonyms gene name: |
tryptase beta 1 |
| Synonyms name: |
tryptase alpha II tryptase beta I tryptase-I tryptase-II tryptase-III |
| Locus: |
16p13, 3 |
| Discovery year: |
1990-11-07 |
| GenBank acession: |
M33494 |
| Entrez gene record: |
7177 |
| Pubmed identfication: |
2203827 9920877 |
| RefSeq identity: |
NM_003294 |
| Havana BLAST/BLAT: |
OTTHUMG00000090467 |