| Category: |
Antibody |
| Concentration: |
09% sodium azide, 4 with 0, In 1X PBS pH 7 |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Cyclin D1 (CCND1) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the CCND1 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This CCND1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q6FI00 |
| Purity: |
Purified |
| Description: |
Cyclins function as regulators of CDK kinases, Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event, Mutations, This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb, amplification and overexpression of the gene encoding this protein, are observed frequently in a variety of tumors and may contribute to tumorigenesis, which alters cell cycle progression, whose activity is required for cell cycle G1/S transition, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle, CCND1 belongs to the highly conserved cyclin family |
| Immunogen: |
A portion of amino acids 147-175 from the human protein was used as the immunogen for this CCND1 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the CCND1 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Cyclin D1 (CCND1) |
| Short name: |
Cyclin D1 Antibody (CCND1) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Cyclin D1 (Antibody to) (cyclin D1) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BCL1 and D11S287E and PRAD1 and U21B31, CCND1 and IDBG-61868 and ENSG00000110092 and 595, CCND1 and IDBG-645012 and ENSBTAG00000017514 and 524530, Ccnd1 and IDBG-212973 and ENSMUSG00000070348 and 12443, DNA-templated and biological process this GO :0006468 and protein phosphorylation and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0007049 and cell cycle and biological process this GO :0007219 and Notch signaling pathway and biological process this GO :0007595 and lactation and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0010033 and response to organic substance and biological process this GO :0010039 and response to iron ion and biological process this GO :0010165 and response to X-ray and biological process this GO :0010243 and response to organonitrogen compound and biological process this GO :0010971 and positive regulation of G2/M transition of mitotic cell cycle and biological process this GO :0014070 and response to organic cyclic compound and biological process this GO :0016020 and membrane and cellular component this GO :0016055 and Wnt signaling pathway and biological process this GO :0016301 and kinase activity and molecular function this GO :0016538 and cyclin-dependent protein serine/threonine kinase regulator activity and molecular function this GO :0017053 and transcriptional repressor complex and cellular component this GO :0019899 and enzyme binding and molecular function this GO :0019901 and protein kinase binding and molecular function this GO :0030178 and negative regulation of Wnt signaling pathway and biological process this GO :0030857 and negative regulation of epithelial cell differentiation and biological process this GO :0030968 and endoplasmic reticulum unfolded protein response and biological process this GO :0031100 and organ regeneration and biological process this GO :0031571 and mitotic G1 DNA damage checkpoint and biological process this GO :0032026 and response to magnesium ion and biological process this GO :0032403 and protein complex binding and molecular function this GO :0033197 and response to vitamin E and biological process this GO :0033327 and Leydig cell differentiation and biological process this GO :0033598 and mammary gland epithelial cell proliferation and biological process this GO :0033601 and positive regulation of mammary gland epithelial cell proliferation and biological process this GO :0042493 and response to drug and biological process this GO :0042826 and histone deacetylase binding and molecular function this GO :0043627 and response to estrogen and biological process this GO :0045444 and fat cell differentiation and biological process this GO :0045471 and response to ethanol and biological process this GO :0045737 and positive regulation of cyclin-dependent protein serine/threonine kinase activity and biological process this GO :0048545 and response to steroid hormone and biological process this GO :0051301 and cell division and biological process this GO :0051384 and response to glucocorticoid and biological process this GO :0051412 and response to corticosterone and biological process this GO :0051592 and response to calcium ion and biological process this GO :0051726 and regulation of cell cycle and biological process this GO :0060070 and canonical Wnt signaling pathway and biological process this GO :0060749 and mammary gland alveolus development and biological process this GO :0070064 and proline-rich region binding and molecular function this GO :0070141 and response to UV-A and biological process this GO :0071157 and negative regulation of cell cycle arrest and biological process this GO :0071310 and cellular response to organic substance and biological process this GO :2000045 and regulation of G1/S transition of mitotic cell cycle and biological process, nuclei, proline-rich region binding, this GO :0000079 and regulation of cyclin-dependent protein serine/threonine kinase activity and biological process this GO :0000082 and G1/S transition of mitotic cell cycle and biological process this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000278 and mitotic cell cycle and biological process this GO :0000307 and cyclin-dependent protein kinase holoenzyme complex and cellular component this GO :0000320 and re-entry into mitotic cell cycle and biological process this GO :0001889 and liver development and biological process this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0003714 and transcription corepressor activity and molecular function this GO :0004672 and protein kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005923 and tight junction and cellular component this GO :0006351 and transcription, this GO :0003714 : transcription corepressor activity, this GO :0003714 : transcription corepressor activity and also this GO :0004672 : protein kinase activity and also this GO :0005515 : protein binding and also this GO :0008134 : transcription factor binding and also this GO :0016301 : kinase activity and also this GO :0016538 : cyclin-dependent protein serine/threonine kinase regulator activity and also this GO :0019899 : enzyme binding and also this GO :0019901 : protein kinase binding and also this GO :0032403 : protein complex binding and also this GO :0042826 : histone deacetylase binding and also this GO :0070064 : proline-rich region binding, this GO :0004672 : protein kinase activity, this GO :0005515 : protein binding, this GO :0008134 : transcription factor binding, this GO :0016301 : kinase activity, this GO :0016538 : cyclin-dependent protein serine/threonine kinase regulator activity, this GO :0019899 : enzyme binding, this GO :0019901 : protein kinase binding, this GO :0032403 : protein complex binding, this GO :0042826 : histone deacetylase binding, this GO :0070064 : proline-rich region binding, cyclin D1 |
| Identity: |
1582 |
| Gene: |
CCND1 |
More about : CCND1 |
| Long gene name: |
cyclin D1 |
| Synonyms gene: |
BCL1 D11S287E PRAD1 |
| Synonyms gene name: |
cyclin D1 (PRAD1: parathyroid adenomatosis 1) |
| Synonyms: |
U21B31 |
| Synonyms name: |
parathyroid adenomatosis 1 B-cell CLL/lymphoma 1 G1/S-specific cyclin D1 |
| Locus: |
11q13, 3 |
| Discovery year: |
1991-06-06 |
| GenBank acession: |
Z23022 |
| Entrez gene record: |
595 |
| Pubmed identfication: |
1826542 1833066 |
| RefSeq identity: |
NM_053056 |
| Classification: |
Cyclins |
| Havana BLAST/BLAT: |
OTTHUMG00000167877 |
| Locus Specific Databases: |
LRG_990 |