| Category: |
Antibody |
| Concentration: |
09% sodium azide, 4 with 0, In 1X PBS pH 7 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
C4B (Complement 4b) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Mouse (Mus musculus) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the C4B antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This C4B antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P0C0L4 |
| Purity: |
Antigen affinity |
| Description: |
2, Deficiency of this protein is associated with systemic lupus erythematosus, In addition, The alpha chain may be cleaved to release C4 anaphylatoxin, The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, The trimer provides a surface for interaction between the antigen-antibody complex and other complement components, This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6, Varying haplotypes of this gene cluster exist, a mediator of local inflammation, and gamma chains prior to secretion, beta, or 3 copies of this gene, part of the classical activation pathway, such that individuals may have 1, this gene exists as a long form and a short form due to the presence or absence of a 6, 4 kb endogenous HERV-K retrovirus in intron 9, This gene encodes the basic form of complement factor 4 |
| Immunogen: |
A portion of amino acids 655-684 from the human protein was used as the immunogen for this C4B antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the C4B antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
C4B (Complement 4b) |
| Short name: |
C4B Antibody (Complement 4b) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
complement component 4B (Chido blood group) (Antibody to) (Complement 4b) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
C4B and IDBG-301132 and ENSG00000224389 and 100293534, C4B_2 and C4B1 and C4B12 and C4B2 and C4B3 and C4B5 and C4BD and C4F and CH and CO4 and CPAMD3, Extracellular, carbohydrate binding, classical pathway and biological process this GO :0008228 and opsonization and biological process this GO :0010951 and negative regulation of endopeptidase activity and biological process this GO :0030246 and carbohydrate binding and molecular function this GO :0030449 and regulation of complement activation and biological process this GO :0032490 and detection of molecule of bacterial origin and biological process this GO :0044216 and other organism cell and cellular component this GO :0045087 and innate immune response and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0072562 and blood microparticle and cellular component this GO :2000427 and positive regulation of apoptotic cell clearance and biological process, this GO :0001848 and complement binding and molecular function this GO :0004866 and endopeptidase inhibitor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005615 and extracellular space and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006954 and inflammatory response and biological process this GO :0006956 and complement activation and biological process this GO :0006958 and complement activation, this GO :0001848 : complement binding, this GO :0001848 : complement binding and also this GO :0004866 : endopeptidase inhibitor activity and also this GO :0005515 : protein binding and also this GO :0030246 : carbohydrate binding, this GO :0004866 : endopeptidase inhibitor activity, this GO :0005515 : protein binding, this GO :0030246 : carbohydrate binding, 721, complement component 4B (Chido blood group) |
| Identity: |
1324 |
| Gene: |
C4B |
More about : C4B |
| Long gene name: |
complement C4B (Chido blood group) |
| Synonyms gene name: |
complement component 4B complement component 4B (Chido blood group) |
| Synonyms: |
CPAMD3 C4F CO4 C4B1 C4B3 CH |
| Locus: |
6p21, 33 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
AF019413 |
| Entrez gene record: |
721 |
| RefSeq identity: |
NM_001002029 |
| Classification: |
Complement system Blood group antigens C3 and PZP like, alpha-2-macroglobulin domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000031187 |
| Locus Specific Databases: |
LRG_138 |