| Gene info: |
Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, SAPK/JNK, These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues, They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, This protein product inactivates ERK2, and different modes of inducibility of their expression by extracellular stimuli, and unlike most other members of this family, different tissue distribution and subcellular localization, is expressed in a variety of tissues with the highest levels in heart and pancreas, is localized in the cytoplasm, p38), which are associated with cellular proliferation and differentiation, The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily |
| Gene names: |
Dual specificity phosphatase 6, Dual specificity protein phosphatase 6, Dual specificity protein phosphatase PYST1, HH19, MAP kinase phosphatase 3, MKP3, PYST1, MKP3 |
| Antibodie's label: |
unlabelled serum |
| Purity: |
Immunoaffinity Purified |
| Ab raised in: |
Chicken |
| Type: |
Polyclonal |
| Antigen: |
135-280 |
| Immuno application: |
Western Blot |
| Antibody advice: |
Dual specificity phosphatase 6 antibody can be used for the detection of Dual specificity phosphatase 6 by Western Blot |
| Suspention, pH, azide: |
No preservatives added, Phosphate-Buffered Saline |
| Keep at: |
Antibodies should not be exposed to prolonged high temperatures, As with all antibodies care should be taken to avoid repeated freeze thaw cycles, Long term storage should be at -20 grades C, DUSP6 antibody can be stored at 4 grades C for short term (weeks) |
| Works with: |
Mouse, Rat, Human |
| Omim nr: |
4503419 |
| Ncbi nr: |
1, NP_001937 |
| KDa: |
1 kDa (calculated), 15 |
| Vial with antibody: |
in solution |
| Quantity per ml: |
1 mg/mL |
| NCBI GENE nr: |
1848 |
| GENE symbol: |
DUSP6 |
| Antigene name: |
dual specificity phosphatase 6 |
| Source: |
Homo sapiens |
| Protein nr: |
Q16828 |
| Description: |
Freeze thaw will destroy a percentage in every cycle and should be avoided, C in a fridge short term in a concentrated dilution, This antibody needs to be stored at + 4° |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by proscience they should be stored frozen at - 24° |
| Gene target: |
DUSP6 |
| Short name: |
anti-DUSP6 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody to, Antibody |
| Alternative name: |
antibody to-dual specificity phosphatase 6 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DUSP6 and IDBG-50524 and ENSG00000139318 and 1848, DUSP6 and IDBG-630730 and ENSBTAG00000004587 and 515310, Dusp6 and IDBG-187794 and ENSMUSG00000019960 and 67603, HH19 and MKP3 and PYST1, MAP kinase tyrosine/serine/threonine phosphatase activity, nuclei, this GO :0000188 and inactivation of MAPK activity and biological process this GO :0001933 and negative regulation of protein phosphorylation and biological process this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002755 and MyD88-dependent toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0004721 and phosphoprotein phosphatase activity and molecular function this GO :0004725 and protein tyrosine phosphatase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006470 and protein dephosphorylation and biological process this GO :0008138 and protein tyrosine/serine/threonine phosphatase activity and molecular function this GO :0009953 and dorsal/ventral pattern formation and biological process this GO :0010033 and response to organic substance and biological process this GO :0010942 and positive regulation of cell death and biological process this GO :0014070 and response to organic cyclic compound and biological process this GO :0016311 and dephosphorylation and biological process this GO :0016791 and phosphatase activity and molecular function this GO :0017017 and MAP kinase tyrosine/serine/threonine phosphatase activity and molecular function this GO :0030154 and cell differentiation and biological process this GO :0034134 and toll-like receptor 2 signaling pathway and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0034146 and toll-like receptor 5 signaling pathway and biological process this GO :0034162 and toll-like receptor 9 signaling pathway and biological process this GO :0034166 and toll-like receptor 10 signaling pathway and biological process this GO :0035335 and peptidyl-tyrosine dephosphorylation and biological process this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0038123 and toll-like receptor TLR1:TLR2 signaling pathway and biological process this GO :0038124 and toll-like receptor TLR6:TLR2 signaling pathway and biological process this GO :0040036 and regulation of fibroblast growth factor receptor signaling pathway and biological process this GO :0042493 and response to drug and biological process this GO :0042663 and regulation of endodermal cell fate specification and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0045087 and innate immune response and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0051403 and stress-activated MAPK cascade and biological process this GO :0051409 and response to nitrosative stress and biological process this GO :0060420 and regulation of heart growth and biological process this GO :0070373 and negative regulation of ERK1 and ERK2 cascade and biological process this GO :0070848 and response to growth factor and biological process, this GO :0004721 : phosphoprotein phosphatase activity, this GO :0004721 : phosphoprotein phosphatase activity and also this GO :0004725 : protein tyrosine phosphatase activity and also this GO :0005515 : protein binding and also this GO :0008138 : protein tyrosine/serine/threonine phosphatase activity and also this GO :0016791 : phosphatase activity and also this GO :0017017 : MAP kinase tyrosine/serine/threonine phosphatase activity, this GO :0004725 : protein tyrosine phosphatase activity, this GO :0005515 : protein binding, this GO :0008138 : protein tyrosine/serine/threonine phosphatase activity, this GO :0016791 : phosphatase activity, this GO :0017017 : MAP kinase tyrosine/serine/threonine phosphatase activity, dual specificity phosphatase 6 |
| Identity: |
3072 |
| Gene: |
DUSP6 |
More about : DUSP6 |
| Long gene name: |
dual specificity phosphatase 6 |
| Synonyms: |
MKP-3 PYST1 |
| Locus: |
12q21, 33 |
| Discovery year: |
1997-03-19 |
| GenBank acession: |
BC037236 |
| Entrez gene record: |
1848 |
| Pubmed identfication: |
8626780 9205128 |
| RefSeq identity: |
NM_001946 NM_022652 |
| Classification: |
MAP kinase phosphatases |
| Havana BLAST/BLAT: |
OTTHUMG00000169912 |