| Gene info: |
<, Patients with SCID present in infancy with recurrent, Pneumocystis carinii, SCID refers to a genetically and clinically group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, The common characteristic of all types of SCID is absence of T cell-mediated cellular immunity due to a defect in T-cell development, The first PTPase domain has enzymatic activity, among many others, and cytomegalovirus, and low or absent antibody levels, including Candida albicans, leukopenia, persistent infections by opportunistic organisms, while the second one seems to affect the substrate specificity of the first one, <, /b>, /b>, : Defects in PTPRC are a cause of autosomal recessive severe combined immunodeficiency T cell-negative/B cell-positive/NK cell-positive (T(-)/B(+)/NK(+) SCID) [MIM:608971], : Required for T-cell activation through the antigen receptor, DISEASE<, FUNCTION<, b>, b> |
| Gene names: |
B220, CD45, CD45 antigen, CD45R, GP180, L-CA, LCA, LY5, Leukocyte common antigen, Receptor-type tyrosine-protein phosphatase C, T200, CD45 |
| Antibodie's label: |
unlabelled serum |
| Purity: |
Immunoaffinity Purified |
| Ab raised in: |
Chicken |
| Type: |
Polyclonal |
| Antigen: |
482-552 |
| Immuno application: |
Western Blot |
| Antibody advice: |
Leukocyte common antigen antibody can be used for the detection of Leukocyte common antigen by Western Blot |
| Suspention, pH, azide: |
No preservatives added, Phosphate-Buffered Saline |
| Keep at: |
Antibodies should not be exposed to prolonged high temperatures, As with all antibodies care should be taken to avoid repeated freeze thaw cycles, Long term storage should be at -20 grades C, PTPRC antibody can be stored at 4 grades C for short term (weeks) |
| Works with: |
Human |
| Omim nr: |
18641347 |
| Ncbi nr: |
2, NP_002829 |
| KDa: |
147, 3 kDa (calculated) |
| Vial with antibody: |
in solution |
| Quantity per ml: |
1 mg/mL |
| NCBI GENE nr: |
5788 |
| GENE symbol: |
PTPRC |
| Antigene name: |
C, receptor type, protein tyrosine phosphatase |
| Source: |
Homo sapiens |
| Protein nr: |
P08575 |
| Description: |
Freeze thaw will destroy a percentage in every cycle and should be avoided, C in a fridge short term in a concentrated dilution, This antibody needs to be stored at + 4° |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by proscience they should be stored frozen at - 24° |
| Gene target: |
PTPRC |
| Short name: |
anti-PTPRC Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody to, Antibody |
| Alternative name: |
C (Antibody to), receptor classification, antibody to-protein tyrosine phosphatase |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
B220 and CD45 and CD45R and GP180 and L-CA and LCA and LY5 and T200, C, Cell surfaces, PTPRC and IDBG-105609 and ENSG00000081237 and 5788, PTPRC and IDBG-638670 and ENSBTAG00000023144 and 407152, Ptprc and IDBG-195821 and ENSMUSG00000026395 and 19264, heparan sulfate proteoglycan binding, receptor type, this GO :0000187 and activation of MAPK activity and biological process this GO :0001915 and negative regulation of T cell mediated cytotoxicity and biological process this GO :0001916 and positive regulation of T cell mediated cytotoxicity and biological process this GO :0001960 and negative regulation of cytokine-mediated signaling pathway and biological process this GO :0002244 and hematopoietic progenitor cell differentiation and biological process this GO :0002378 and immunoglobulin biosynthetic process and biological process this GO :0002711 and positive regulation of T cell mediated immunity and biological process this GO :0002923 and regulation of humoral immune response mediated by circulating immunoglobulin and biological process this GO :0002925 and positive regulation of humoral immune response mediated by circulating immunoglobulin and biological process this GO :0004725 and protein tyrosine phosphatase activity and molecular function this GO :0005001 and transmembrane receptor protein tyrosine phosphatase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0005925 and focal adhesion and cellular component this GO :0006469 and negative regulation of protein kinase activity and biological process this GO :0006470 and protein dephosphorylation and biological process this GO :0006933 and negative regulation of cell adhesion involved in substrate-bound cell migration and biological process this GO :0007159 and leukocyte cell-cell adhesion and biological process this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0007411 and axon guidance and biological process this GO :0008201 and heparin binding and molecular function this GO :0009897 and external side of plasma membrane and cellular component this GO :0009986 and cell surface and cellular component this GO :0010332 and response to gamma radiation and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016311 and dephosphorylation and biological process this GO :0016791 and phosphatase activity and molecular function this GO :0019901 and protein kinase binding and molecular function this GO :0030183 and B cell differentiation and biological process this GO :0030217 and T cell differentiation and biological process this GO :0030890 and positive regulation of B cell proliferation and biological process this GO :0031953 and negative regulation of protein autophosphorylation and biological process this GO :0034113 and heterotypic cell-cell adhesion and biological process this GO :0035335 and peptidyl-tyrosine dephosphorylation and biological process this GO :0042098 and T cell proliferation and biological process this GO :0042100 and B cell proliferation and biological process this GO :0042102 and positive regulation of T cell proliferation and biological process this GO :0043395 and heparan sulfate proteoglycan binding and molecular function this GO :0043410 and positive regulation of MAPK cascade and biological process this GO :0044770 and cell cycle phase transition and biological process this GO :0045059 and positive thymic T cell selection and biological process this GO :0045060 and negative thymic T cell selection and biological process this GO :0045087 and innate immune response and biological process this GO :0045121 and membrane raft and cellular component this GO :0045577 and regulation of B cell differentiation and biological process this GO :0045582 and positive regulation of T cell differentiation and biological process this GO :0045588 and positive regulation of gamma-delta T cell differentiation and biological process this GO :0045860 and positive regulation of protein kinase activity and biological process this GO :0046641 and positive regulation of alpha-beta T cell proliferation and biological process this GO :0048304 and positive regulation of isotype switching to IgG isotypes and biological process this GO :0048539 and bone marrow development and biological process this GO :0048864 and stem cell development and biological process this GO :0050732 and negative regulation of peptidyl-tyrosine phosphorylation and biological process this GO :0050852 and T cell receptor signaling pathway and biological process this GO :0050853 and B cell receptor signaling pathway and biological process this GO :0050855 and regulation of B cell receptor signaling pathway and biological process this GO :0050857 and positive regulation of antigen receptor-mediated signaling pathway and biological process this GO :0051209 and release of sequestered calcium ion into cytosol and biological process this GO :0051607 and defense response to virus and biological process this GO :0051726 and regulation of cell cycle and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0071944 and cell periphery and cellular component this GO :2000473 and positive regulation of hematopoietic stem cell migration and biological process this GO :2000648 and positive regulation of stem cell proliferation and biological process this GO :2001236 and regulation of extrinsic apoptotic signaling pathway and biological process this GO :2001238 and positive regulation of extrinsic apoptotic signaling pathway and biological process, this GO :0004725 : protein tyrosine phosphatase activity, this GO :0004725 : protein tyrosine phosphatase activity and also this GO :0005001 : transmembrane receptor protein tyrosine phosphatase activity and also this GO :0005515 : protein binding and also this GO :0008201 : heparin binding and also this GO :0016791 : phosphatase activity and also this GO :0019901 : protein kinase binding and also this GO :0043395 : heparan sulfate proteoglycan binding, this GO :0005001 : transmembrane receptor protein tyrosine phosphatase activity, this GO :0005515 : protein binding, this GO :0008201 : heparin binding, this GO :0016791 : phosphatase activity, this GO :0019901 : protein kinase binding, this GO :0043395 : heparan sulfate proteoglycan binding, protein tyrosine phosphatase |
| Identity: |
9666 |
| Gene: |
PTPRC |
More about : PTPRC |
| Long gene name: |
protein tyrosine phosphatase, receptor type C |
| Synonyms gene: |
CD45 |
| Synonyms: |
LCA T200 GP180 |
| Locus: |
1q31, 1 , 3-q32 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
Y00062 |
| Entrez gene record: |
5788 |
| Pubmed identfication: |
2169617 |
| RefSeq identity: |
NM_002838 |
| Classification: |
Fibronectin type III domain containing CD molecules Protein tyrosine phosphatases, receptor type |
| Havana BLAST/BLAT: |
OTTHUMG00000035702 |
| Locus Specific Databases: |
PTPRCbase: Mutation registry for CD45 deficiency LRG_95 |