| Gene info: |
<, Binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') found in the tyrosinase promoter, It is an autosomal dominant disorder characterized by generalized hypopigmentation and profound, Penetrance is complete, Plays a critical role in the differentiation of various cell types as neural crest-derived melanocytes, bilateral deafness, congenital, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium, <, /b>, /b>, : Defects in MITF are the cause of Tietz syndrome [MIM:103500], : Transcription factor for tyrosinase and tyrosinase-related protein 1, DISEASE<, FUNCTION<, b>, b> |
| Gene names: |
CMM8, Class E basic helix-loop-helix protein 32, MI, Microphthalmia-associated transcription factor, Microphthalmiaassociated transcription factor, WS2, WS2A, bHLHe32, BHLHE32 |
| Antibodie's label: |
unlabelled serum |
| Purity: |
Immunoaffinity Purified |
| Ab raised in: |
Chicken |
| Type: |
Polyclonal |
| Antigen: |
287-417 |
| Immuno application: |
Western Blot |
| Antibody advice: |
Microphthalmia-associated transcription factor antibody can be used for the detection of Microphthalmia-associated transcription factor by Western Blot |
| Suspention, pH, azide: |
No preservatives added, Phosphate-Buffered Saline |
| Keep at: |
Antibodies should not be exposed to prolonged high temperatures, As with all antibodies care should be taken to avoid repeated freeze thaw cycles, Long term storage should be at -20 grades C, MITF antibody can be stored at 4 grades C for short term (weeks) |
| Works with: |
Human |
| Omim nr: |
4557755 |
| Ncbi nr: |
1, NP_000239 |
| KDa: |
58, 8 kDa (calculated) |
| Vial with antibody: |
in solution |
| Quantity per ml: |
1 mg/mL |
| NCBI GENE nr: |
4286 |
| GENE symbol: |
MITF |
| Antigene name: |
microphthalmia-associated transcription factor |
| Source: |
Homo sapiens |
| Protein nr: |
O75030 |
| Description: |
Freeze thaw will destroy a percentage in every cycle and should be avoided, C in a fridge short term in a concentrated dilution, This antibody needs to be stored at + 4° |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by proscience they should be stored frozen at - 24° |
| Gene target: |
MITF |
| Short name: |
anti-MITF Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody to, Antibody |
| Alternative name: |
antibody to-microphthalmia-associated transcription factor (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BT, DNA-templated and biological process this GO :0006366 and transcription from RNA polymerase II promoter and biological process this GO :0006461 and protein complex assembly and biological process this GO :0010468 and regulation of gene expression and biological process this GO :0016055 and Wnt signaling pathway and biological process this GO :0030154 and cell differentiation and biological process this GO :0030316 and osteoclast differentiation and biological process this GO :0030318 and melanocyte differentiation and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0043010 and camera-type eye development and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043234 and protein complex and cellular component this GO :0043473 and pigmentation and biological process this GO :0044336 and canonical Wnt signaling pathway involved in negative regulation of apoptotic process and biological process this GO :0045165 and cell fate commitment and biological process this GO :0045670 and regulation of osteoclast differentiation and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046849 and bone remodeling and biological process this GO :0046983 and protein dimerization activity and molecular function, MITF and IDBG-44086 and ENSG00000187098 and 4286, Mitf and IDBG-172461 and ENSMUSG00000035158 and 17342, bHLHe32 and CMM8 and MI and WS2 and WS2A, nuclei, protein dimerization activity, this GO :0000978 and RNA polymerase II core promoter proximal region sequence-specific DNA binding and molecular function this GO :0000979 and RNA polymerase II core promoter sequence-specific DNA binding and molecular function this GO :0001077 and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription and molecular function this GO :0003677 and DNA binding and molecular function this GO :0003682 and chromatin binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0003705 and RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0006355 and regulation of transcription, this GO :0000978 : RNA polymerase II core promoter proximal region sequence-specific DNA binding, this GO :0000978 : RNA polymerase II core promoter proximal region sequence-specific DNA binding and also this GO :0000979 : RNA polymerase II core promoter sequence-specific DNA binding and also this GO :0001077 : RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription and also this GO :0003677 : DNA binding and also this GO :0003682 : chromatin binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0003705 : RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity and also this GO :0005515 : protein binding and also this GO :0046983 : protein dimerization activity, this GO :0000979 : RNA polymerase II core promoter sequence-specific DNA binding, this GO :0001077 : RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription, this GO :0003677 : DNA binding, this GO :0003682 : chromatin binding, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0003705 : RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity, this GO :0005515 : protein binding, this GO :0046983 : protein dimerization activity, 29882 and IDBG-644985 and ENSBTAG00000006679 and 407219, microphthalmia-associated transcription factor |
| Identity: |
7105 |
| Gene: |
MITF |
More about : MITF |
| Long gene name: |
melanogenesis associated transcription factor |
| Synonyms gene: |
WS2A WS2 |
| Synonyms gene name: |
Waardenburg syndrome, type 2A microphthalmia-associated transcription factor |
| Synonyms: |
MI bHLHe32 |
| Synonyms name: |
homolog of mouse microphthalmia |
| Locus: |
3p13 |
| Discovery year: |
1993-10-27 |
| Entrez gene record: |
4286 |
| Pubmed identfication: |
8069297 7874167 7951321 |
| RefSeq identity: |
NM_198159 |
| Classification: |
Basic helix-loop-helix proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000149921 |
| Locus Specific Databases: |
LOVD - Leiden Open Variation Database LRG_776 |