| Gene info: |
Fas gene mutations have been suggested to have a role in testicular germ cell tumors, Functional impairment of the Fas / Fas Ligand system is associated with the development and progression of malignancies, Ligation of Fas by Fas Ligand or an anti Fas cross linking antibody, The apoptosis of lymphocytes, Tumor cells frequently exhibit de novo expression of Fas Ligand, and immune escape of the tumor cells, is usually induced by the Fas/Fas Ligand system, metastatic spread, triggers activation of the caspase cascade, which occurs in autoimmune diseases, which plays a significant role in local tissue destruction, Fas Ligand is an important member of the tumour necrosis factor (TNF) superfamily involved in membrane mediated apoptosis |
| Gene names: |
ALPS1B, APT1LG1, APTL, Apoptosis antigen ligand, CD178, CD95-L, CD95L, FASL, TNFSF6, Tumor necrosis factor ligand superfamily member 6, APTL |
| Antibodie's label: |
unlabelled serum |
| Purity: |
Anti-hFasL specific antibody was purified by affinity chromatography employing immobilized hFasL matrix |
| Ab raised in: |
Goat |
| Type: |
Polyclonal |
| Antigen: |
98%) recombinant hFasL (human FAS Ligand), Produced from sera of goats pre-immunized with highly pure (> |
| Immuno application: |
NELISAut, Western Blot, ELISA |
| Antibody advice: |
ELISA: To detect hFasL by direct ELISA (using 100 &, This antigen affinity purified antibody, Used in conjunction with compatible secondary reagents the detection limit for recombinant hFasL is 1, Western Blot: To detect hFasL by Western Blot analysis this antibody can be used at a concentration of 0, a concentration of 0, allows the detection of 0, in conjunction with compatible secondary reagents, under either reducing or non-reducing conditions, #956, 0 ng/lane, 08 - 0, 1 - 0, 1 ug/mL of this antibody is required, 2 - 0, 2 ug/mL, 4 ng/well of recombinant hFasL, 5 - 3, 5 ug/mL of this antibody is required, L/well antibody solution) a concentration of at least 0, Neutralization: To yield one-half maximal inhibition [ND50] of the biological activity of FasL/Apo1L (10 ng/mL) |
| Keep at: |
Avoid repeated freeze-thaw cycles, Frozen aliquots are stable for at least 6 months when stored at -20 grades C, The reconstituted antibody is stable for at least two weeks at 2-8 grades C, Fas Ligand antibody is stable for at least 2 years from date of receipt at -20 grades C |
| Works with: |
Human |
| Omim nr: |
1345957 |
| Ncbi nr: |
P48023 |
| Vial with antibody: |
Lyophilized |
| NCBI GENE nr: |
356 |
| GENE symbol: |
FASLG |
| Antigene name: |
member 6), Fas ligand (TNF superfamily |
| Source: |
Homo sapiens |
| Protein nr: |
P48023 |
| Description: |
FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling, Freeze thaw will destroy a percentage in every cycle and should be avoided, Receptor agonists are often tested for drug development, C in a fridge short term in a concentrated dilution, This antibody needs to be stored at + 4° |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by proscience they should be stored frozen at - 24° |
| Gene target: |
Fas Ligand |
| Short name: |
anti-Fas Ligand Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody to, Antibody |
| Alternative name: |
member 6) Ligand (Antibody to), antibody to-Fas (TNF receptor superfamily |
| Alternative technique: |
antibodies |