| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
SH2D1A |
| Specificity: |
This antibody reacts specifically with SH2D1A |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human SH2D1A/SAP |
| Gene ID: |
4068 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
128 amino acid protein that is 96% homologous to the mouse protein in both SH2 and tail domains, CD229 (LY9) and CD244 (2B4), CD45RA+ and CD8+, CD45RO+, CD84, SAP and CD150/SLAM (signaling lymphocyte activation molecule)-associated protein, SH2D1A can interact via an SH2 domain with a motif (TIYXXV) present in the cytoplasmic tail of cell-surface receptors SLAM (CD150), SH2D1A is a hydrophilic, SH2D1A is present in all major subsets of T cells, SH2D1A modulates SLAM by blocking the recruitment of tyrosine phosphatase SHP2 to the phosphorylated cytoplasmic domain of SLAM, SLAM activation mediates expansion of activated T cells during immune responses, also SH2 domain protein 1A, but not in B cells, including CD4+, induces production of interferon-?and changes the functional profile of subsets of T cells, influences signaling pathways involving SLAM molecules at the interface between T and B cells, SH2D1A |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
XLP MTCP1 DSHP XLPD EBVS SAP |
| Also known as: |
SH2D1A Polyclonal Antibody |
| Other name: |
Anti-SH2D1A Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
SH2D1A |
| Short name: |
Anti-SH2D1A (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-SH2 domain containing 1A (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
Cytoplasm, DSHP and EBVS and IMD5 and LYP and MTCP1 and SAP and SAP/SH2D1A and XLP and XLPD and XLPD1, SH2D1A and IDBG-630222 and ENSBTAG00000026067 and 613356, SH2D1A and IDBG-85368 and ENSG00000183918 and 4068, Sh2d1a and IDBG-141610 and ENSMUSG00000005696 and 20400, protein binding, this GO :0005070 and SH3/SH2 adaptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0006959 and humoral immune response and biological process this GO :0006968 and cellular defense response and biological process this GO :0007267 and cell-cell signaling and biological process this GO :0009967 and positive regulation of signal transduction and biological process this GO :0045087 and innate immune response and biological process this GO :0045954 and positive regulation of natural killer cell mediated cytotoxicity and biological process, this GO :0005070 : SH3/SH2 adaptor activity, this GO :0005070 : SH3/SH2 adaptor activity and also this GO :0005515 : protein binding, this GO :0005515 : protein binding, SH2 domain containing 1A |
| Identity: |
10820 |
| Gene: |
SH2D1A |
More about : SH2D1A |
| Long gene name: |
SH2 domain containing 1A |
| Synonyms gene: |
IMD5 LYP |
| Synonyms gene name: |
lymphoproliferative syndrome SH2 domain protein 1A |
| Synonyms name: |
Duncan', s disease |
| Locus: |
Xq25 |
| Discovery year: |
1989-06-30 |
| GenBank acession: |
AL023657 |
| Entrez gene record: |
4068 |
| Pubmed identfication: |
9771704 9774102 |
| RefSeq identity: |
NM_002351 |
| Classification: |
SH2 domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000022344 |
| Locus Specific Databases: |
SH2D1Abase: Mutation registry for X-linked lymphoproliferative syndrome (XLP) LRG_106 |