| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Aconitase 1 |
| Specificity: |
This antibody reacts specifically with Aconitase 1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Aconitase 1/IRP-1 |
| Gene ID: |
48 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
IRP-1 and IRP-2 are important soluble regulatory factors that mediate iron uptake and storage in mammalian cells, IRPs respond to stress mediators, Iron uptake and distribution is a highly regulated process in mammalian cells that is monitored by two iron sensing proteins, They are capable of either repressing translation or enhancing mRNA stability by associating with stem-loop motifs known as iron-responsive elements (IREs), also known as iron responsive element-binding protein-1 and -2 (IREâ, cytokines and hydrogen peroxide, including nitrogen monoxide, iron concentration and signaling factors, iron regulatory protein-1 and -2 (IRP-1 and -2), &euro, &ldquo, BP-1 and -2) or aconitase 1 and 2, Iron metabolism is essential for sustaining mammalian homeostasis |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
IRP1 IREBP |
| Also known as: |
Aconitase 1 Polyclonal Antibody |
| Other name: |
Anti-Aconitase 1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Aconitase 1 |
| Short name: |
Anti-Aconitase 1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Aconitase 1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
117 |
| Gene: |
ACO1 |
More about : ACO1 |
| Long gene name: |
aconitase 1 |
| Synonyms gene: |
IREB1 |
| Synonyms gene name: |
aconitase 1, soluble |
| Synonyms name: |
aconitate hydratase, cytoplasmic soluble aconitase cytosplasmic aconitase |
| Locus: |
9p21, 1 |
| Discovery year: |
1989-01-01 |
| GenBank acession: |
M58510 |
| Entrez gene record: |
48 |
| Pubmed identfication: |
2172968 2771641 |
| RefSeq identity: |
NM_002197 |
| Havana BLAST/BLAT: |
OTTHUMG00000019740 |