| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
BIN2 |
| Specificity: |
This antibody reacts specifically with BIN2 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human BIN2/BRAP1 |
| Gene ID: |
51411 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
BIN1 (Bridging integrator 1) is a ubiquitously expressed regulatory protein for synaptic vesicle endocytosis, BIN1 also interacts with the transcription factors c-Myc and MyoD, BIN1 and BIN2 are BAR proteins that share 61% sequence similarity, BIN2, BIN2 lacks tumor suppressor features as well as a c-Myc interacting region, BIN2 shows preferred expression in tissues of hematopoietic origin, In contrast to BIN1, There are two isoforms of BIN2 that are produced as a result of alternative splicing events, also known as Breast cancer-associated protein 1, amphiphysin and Rvs161/167) domain and are recognized as adaptor proteins that are involved in many cellular processes, colon, is a 565 amino acid protein that interacts with BIN1, lymphoid and granulocytic cells, placenta, potentially functioning as a tumor suppressor, thymus, with high levels found in spleen, BAR proteins are characterized by a common N-terminal BAR (bin |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
BRAP-1 |
| Also known as: |
BIN2 Polyclonal Antibody |
| Other name: |
Anti-BIN2 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
BIN2 |
| Short name: |
Anti-BIN2 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-BIN2 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
1053 |
| Gene: |
BIN2 |
More about : BIN2 |
| Long gene name: |
bridging integrator 2 |
| Locus: |
12q13, 13 |
| Discovery year: |
2000-05-25 |
| GenBank acession: |
AF146531 |
| Entrez gene record: |
51411 |
| Pubmed identfication: |
10903846 |
| Classification: |
N-BAR domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000185197 |