| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CDX1 |
| Specificity: |
This antibody reacts specifically with CDX1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human CDX1 |
| Gene ID: |
1044 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
A decrease in human Cdx1 and/or Cdx2 expression is associated with colorectal tumorigenesis, Both Cdx1 and Cdx2 genes must be expressed to reduce tumorigenic potential, Cdx1 and Cdx2 are expressed in the small intestine and colon of fetus and adult, Cdx1 positively regulates its own expression, Cdx2, Expression of the Cdx1 homeobox gene in epithelial intestinal cells promotes cellular growth and differentiation, The human Cdx1 gene maps to chromosome 5q31-q33 and encodes a 265-amino acid protein, The intestine-specific transcription factors Cdx1 and Cdx2 are candidate genes for directing intestinal development, The relative expression of Cdx1 to Cdx2 protein may be important in the anterior to posterior patterning of the intestinal epithelium and in defining patterns of proliferation and differentiation along the crypt-villus axis, and Cdx4) are members of the caudal-type homeobox family of genes, differentiation, gene required for anterior-posterior regional identity, proliferation and maintenance of the intestinal phenotype, suggesting that the two genes control the normal phenotype by independent pathways, to increase sensitivity to apoptosis and to reduce cell migration, which are homologues of the Drosophila â, &euro, &euro, &tilde, &trade, The members of the murine Cdx family (Cdx1, caudalâ |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
CDX1 Polyclonal Antibody |
| Other name: |
Anti-CDX1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
CDX1 |
| Short name: |
Anti-CDX1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-CDX1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
1805 |
| Gene: |
CDX1 |
More about : CDX1 |
| Long gene name: |
caudal type homeobox 1 |
| Synonyms gene name: |
caudal type homeo box transcription factor 1 |
| Locus: |
5q32 |
| Discovery year: |
1995-05-05 |
| GenBank acession: |
U51095 |
| Entrez gene record: |
1044 |
| Pubmed identfication: |
8530027 |
| RefSeq identity: |
NM_001804 |
| Classification: |
HOXL subclass homeoboxes |
| Havana BLAST/BLAT: |
OTTHUMG00000169772 |