| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CSN1 |
| Specificity: |
This antibody reacts specifically with CSN1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human CSN1 |
| Gene ID: |
2873 |
| Swiss Prot: |
Q13098 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
CSA or DDB2, CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, ITPK1 and IRF8/ICSBP, IkappaBalpha/NFKBIA, Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction, The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, The complex is also involved in phosphorylation of p53/TP53, a complex involved in various cellular and developmental processes, c-jun/JUN, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, possibly via its association with CK2 and PKD kinases, respectively, Essential component of the COP9 signalosome complex (CSN) |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
COPS1 CSN1 |
| Also known as: |
CSN1 Polyclonal Antibody |
| Other name: |
Anti-CSN1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
CSN1 |
| Short name: |
Anti-CSN1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-CSN1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
4549 |
| Gene: |
GPS1 |
More about : GPS1 |
| Long gene name: |
G protein pathway suppressor 1 |
| Synonyms name: |
COP9 signalosome subunit 1 |
| Locus: |
17q25, 3 |
| Discovery year: |
1997-10-10 |
| Entrez gene record: |
2873 |
| Pubmed identfication: |
9535219 |
| RefSeq identity: |
NM_212492 |
| Classification: |
COP9 signalosome |
| Havana BLAST/BLAT: |
OTTHUMG00000178484 |