| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
MEPE |
| Specificity: |
This antibody reacts specifically with MEPE |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human MEPE |
| Gene ID: |
56955 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Expressed in osteocytes and brain, MEPE contains an RGD cell-attachment motif and shares molecular similarities with several dentin-bone extracellular matrix RGD-containing phosphoglycoproteins, MEPE is a regulator of bone metabolism that is thought to mediate mineralization and demineralization within the osteocyte microenvironment, MEPE is associated with various developmental events such as skeletogenesis, MEPE is secreted in hypophosphatemic osteomalacia tumors, Via its ability to control bone mineralization, bone regeneration and odontogenesis, including OPN (osteopontin) and DSP (dentin sialophosphoprotein), suggesting a possible role in the pathophysiology of bone-related cancers, MEPE is a 525 amino acid extracellular matrix protein |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
MEPE Polyclonal Antibody |
| Other name: |
Anti-MEPE Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
MEPE |
| Short name: |
Anti-MEPE (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-MEPE (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
13361 |
| Gene: |
MEPE |
More about : MEPE |
| Long gene name: |
matrix extracellular phosphoglycoprotein |
| Synonyms gene name: |
extracellular phosphoglycoprotein with ASARM motif (bone) , matrix |
| Locus: |
4q22, 1 |
| Discovery year: |
2000-09-19 |
| GenBank acession: |
AJ276396 |
| Entrez gene record: |
56955 |
| Pubmed identfication: |
10945470 |
| Classification: |
SIBLING family |
| Havana BLAST/BLAT: |
OTTHUMG00000130592 |