| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
MSH3 |
| Specificity: |
This antibody reacts specifically with MSH3 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human MSH3 |
| Gene ID: |
4437 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
After mismatch binding, Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair, MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long, When bound, and resynthesis, excision, forms a ternary complex with the MutL alpha heterodimer, including strand discrimination, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs, which is thought to be responsible for directing the downstream MMR events, Component of the post-replicative DNA mismatch repair system (MMR) |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
DUP MRP1 |
| Also known as: |
MSH3 Polyclonal Antibody |
| Other name: |
Anti-MSH3 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
MSH3 |
| Short name: |
Anti-MSH3 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, coli) (polyclonal), antibody to-mutS homolog 3 (E |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
DUP and MRP1, MSH3 and IDBG-31502 and ENSG00000113318 and 4437, MSH3 and IDBG-646483 and ENSBTAG00000007684 and 616744, Msh3 and IDBG-171801 and ENSMUSG00000014850 and 17686, coli), nuclei, oxidized purine DNA binding, this GO :0000228 and nuclear chromosome and cellular component this GO :0000403 and Y-form DNA binding and molecular function this GO :0000404 and heteroduplex DNA loop binding and molecular function this GO :0000406 and double-strand/single-strand DNA junction binding and molecular function this GO :0000710 and meiotic mismatch repair and biological process this GO :0003677 and DNA binding and molecular function this GO :0003684 and damaged DNA binding and molecular function this GO :0003697 and single-stranded DNA binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0006200 and ATP catabolic process and biological process this GO :0006281 and DNA repair and biological process this GO :0006298 and mismatch repair and biological process this GO :0007131 and reciprocal meiotic recombination and biological process this GO :0008094 and DNA-dependent ATPase activity and molecular function this GO :0016020 and membrane and cellular component this GO :0016447 and somatic recombination of immunoglobulin gene segments and biological process this GO :0019237 and centromeric DNA binding and molecular function this GO :0019899 and enzyme binding and molecular function this GO :0030983 and mismatched DNA binding and molecular function this GO :0032139 and dinucleotide insertion or deletion binding and molecular function this GO :0032142 and single guanine insertion binding and molecular function this GO :0032181 and dinucleotide repeat insertion binding and molecular function this GO :0032302 and MutSbeta complex and cellular component this GO :0032357 and oxidized purine DNA binding and molecular function this GO :0043570 and maintenance of DNA repeat elements and biological process this GO :0045910 and negative regulation of DNA recombination and biological process this GO :0051096 and positive regulation of helicase activity and biological process, this GO :0000403 : Y-form DNA binding, this GO :0000403 : Y-form DNA binding and also this GO :0000404 : heteroduplex DNA loop binding and also this GO :0000406 : double-strand/single-strand DNA junction binding and also this GO :0003677 : DNA binding and also this GO :0003684 : damaged DNA binding and also this GO :0003697 : single-stranded DNA binding and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0008094 : DNA-dependent ATPase activity and also this GO :0019237 : centromeric DNA binding and also this GO :0019899 : enzyme binding and also this GO :0030983 : mismatched DNA binding and also this GO :0032139 : dinucleotide insertion or deletion binding and also this GO :0032142 : single guanine insertion binding and also this GO :0032181 : dinucleotide repeat insertion binding and also this GO :0032357 : oxidized purine DNA binding, this GO :0000404 : heteroduplex DNA loop binding, this GO :0000406 : double-strand/single-strand DNA junction binding, this GO :0003677 : DNA binding, this GO :0003684 : damaged DNA binding, this GO :0003697 : single-stranded DNA binding, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0008094 : DNA-dependent ATPase activity, this GO :0019237 : centromeric DNA binding, this GO :0019899 : enzyme binding, this GO :0030983 : mismatched DNA binding, this GO :0032139 : dinucleotide insertion or deletion binding, this GO :0032142 : single guanine insertion binding, this GO :0032181 : dinucleotide repeat insertion binding, this GO :0032357 : oxidized purine DNA binding, mutS homolog 3 (E |
| Identity: |
7326 |
| Gene: |
MSH3 |
More about : MSH3 |
| Long gene name: |
mutS homolog 3 |
| Synonyms gene name: |
coli) , coli) homolog 3 mutS homolog 3 (E, mutS (E |
| Synonyms name: |
Divergent upstream protein Mismatch repair protein 1 |
| Locus: |
5q14, 1 |
| Discovery year: |
1995-09-28 |
| GenBank acession: |
U61981 |
| Entrez gene record: |
4437 |
| RefSeq identity: |
NM_002439 |
| Classification: |
MutS homologs |
| Havana BLAST/BLAT: |
OTTHUMG00000162540 |